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Bos EJ, Pluemeekers M, Helder M, et al. Structural and Mechanical Comparison of Human Ear, Alar, and Septal Cartilage. Plast Reconstr Surg Glob Open. 2018;6(1):e1610doi: 10.1097/GOX.0000000000001610.
Bos, E. J., Pluemeekers, M., Helder, M., Kuzmin, N., van der Laan, K., Groot, M. L., van Osch, G., & van Zuijlen, P. (2018). Structural and Mechanical Comparison of Human Ear, Alar, and Septal Cartilage. Plastic and reconstructive surgery. Global open, 6(1), e1610. https://doi.org/10.1097/GOX.0000000000001610
Bos, Ernst Jan, et al. "Structural and Mechanical Comparison of Human Ear, Alar, and Septal Cartilage." Plastic and reconstructive surgery. Global open vol. 6,1 (2018): e1610. doi: https://doi.org/10.1097/GOX.0000000000001610
Bos EJ, Pluemeekers M, Helder M, Kuzmin N, van der Laan K, Groot ML, van Osch G, van Zuijlen P. Structural and Mechanical Comparison of Human Ear, Alar, and Septal Cartilage. Plast Reconstr Surg Glob Open. 2018 Jan 18;6(1):e1610. doi: 10.1097/GOX.0000000000001610. eCollection 2018 Jan. PMID: 29464156; PMCID: PMC5811286.
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Plast Reconstr Surg Glob Open. 2018 Jan 18;6(1):e1610. doi: 10.1097/GOX.0000000000001610. eCollection 2018 Jan.

Structural and Mechanical Comparison of Human Ear, Alar, and Septal Cartilage.

Plastic and reconstructive surgery. Global open

Ernst Jan Bos, Mieke Pluemeekers, Marco Helder, Nikolay Kuzmin, Koen van der Laan, Marie-Louise Groot, Gerjo van Osch, Paul van Zuijlen

Affiliations

  1. Department of Plastic, Reconstructive and Hand Surgery, VU Medical Center, Amsterdam, The Netherlands; CTRM/MOVE Research Institute, Amsterdam, The Netherlands; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Orthopedic Surgery, VU Medical Center, Amsterdam, The Netherlands; LaserLab Amsterdam, Department of Physics, Free University, Amsterdam, The Netherlands; Department of Physics and LaserLab, Free University, Amsterdam, The Netherlands; Department of Orthopaedics, Erasmus University Medical Center, Rotterdam, The Netherlands; and Red Cross Hospital Beverwijk, Beverwijk, The Netherlands.

PMID: 29464156 PMCID: PMC5811286 DOI: 10.1097/GOX.0000000000001610

Abstract

BACKGROUND: In the human ear and nose, cartilage plays a key role in establishing its form and function. Interestingly, there is a noticeable paucity on biochemical, structural, and mechanical studies focused on facial cartilage. Such studies are needed to provide elementary knowledge that is fundamental to tissue engineering of cartilage. Therefore, in this study, a comparison is made of the biochemical, structural, and mechanical differences between ear, ala nasi, and septum on the extracellular matrix (ECM) level.

METHODS: Cartilage samples were harvested from 10 cadaveric donors. Each sample was indented 10 times with a nanoindenter to determine the effective Young's modulus. Structural information of the cartilage was obtained by multiple-photon laser scanning microscopy capable of revealing matrix components at subcellular resolution. Biochemistry was performed to measure glycosaminoglycan (GAG), DNA, elastin, and collagen content.

RESULTS: Significant differences were seen in stiffness between ear and septal cartilage (

CONCLUSION: Proposed methods to investigate cartilage on the ECM level provided good results. Significant differences were seen not only between ear and nasal cartilage but also between the ala nasi and septal cartilage. Albeit its structural similarity to septal cartilage, the ala nasi has a matrix stiffness comparable to ear cartilage.

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