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García de Cortázar U, Padilla S, Lobato E, et al. Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report. J Clin Med. 2018;7(2)doi: 10.3390/jcm7020013.
García de Cortázar, U., Padilla, S., Lobato, E., Delgado, D., & Sánchez, M. (2018). Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report. Journal of clinical medicine, 7(2), . https://doi.org/10.3390/jcm7020013
García de Cortázar, Unai, et al. "Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report." Journal of clinical medicine vol. 7,2 (2018). doi: https://doi.org/10.3390/jcm7020013
García de Cortázar U, Padilla S, Lobato E, Delgado D, Sánchez M. Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report. J Clin Med. 2018 Jan 29;7(2). doi: 10.3390/jcm7020013. PMID: 29382110; PMCID: PMC5852429.
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J Clin Med. 2018 Jan 29;7(2). doi: 10.3390/jcm7020013.

Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report.

Journal of clinical medicine

Unai García de Cortázar, Sabino Padilla, Enrique Lobato, Diego Delgado, Mikel Sánchez

Affiliations

  1. Service of Orthopedic Surgery and Traumatology, Basurto Hospital, 48013 Bilbao, Spain. [email protected].
  2. University Institute for Regenerative Medicine and Oral Implantology-UIRMI, University of the Basque Country, Vitoria, 01007 Vitoria-Gasteiz, Spain. [email protected].
  3. Service of Orthopedic Surgery and Traumatology, Basurto Hospital, 48013 Bilbao, Spain. [email protected].
  4. Advanced Biological Therapy Unit, Hospital Vithas San José, 01008 Vitoria-Gasteiz, Spain. [email protected].
  5. Advanced Biological Therapy Unit, Hospital Vithas San José, 01008 Vitoria-Gasteiz, Spain. [email protected].
  6. Arthroscopic Surgery Unit, Hospital Vithas San José, 01008 Vitoria-Gasteiz, Spain. [email protected].

PMID: 29382110 PMCID: PMC5852429 DOI: 10.3390/jcm7020013

Abstract

The radial nerve is the most frequently injured nerve in the upper extremity. Numerous options in treatment have been described for radial nerve injury, such as neurolysis, nerve grafts, or tendon transfers. Currently, new treatment options are arising, such as platelet-rich plasma (PRP), an autologous product with proved therapeutic effect for various musculoskeletal disorders. We hypothesized that this treatment is a promising alternative for this type of nerve pathology. The patient was a healthy 27-year-old man who suffered a deep and long cut in the distal anterolateral region of the right arm. Forty-eight hours after injury, an end-to-end suture was performed without a microscope. Three months after the surgery, an electromyogram (EMG) showed right radial nerve neurotmesis with no tendency to reinnervation. Four months after the trauma, serial intraneural infiltrations of PRP were conducted using ultrasound guidance. The therapeutic effect was assessed by manual muscle testing and by EMG. Fourteen months after the injury and 11 months after the first PRP injection, functional recovery was achieved. The EMG showed a complete reinnervation of the musculature of the radial nerve dependent. The patient remains satisfied with the result and he is able to practice his profession.

CONCLUSIONS: PRP infiltrations have the potential to enhance the healing process of radial nerve palsy. This case report demonstrates the therapeutic potential of this technology for traumatic peripheral nerve palsy, as well as the apt utility of US-guided PRP injections.

Keywords: intraneural injections; platelet-rich plasma; radial nerve section

Conflict of interest statement

Sabino Padilla declares the following competing financial interest: Sabino Padilla is scientist at BTI Biotechnology Institute, a dental implant company that investigates the fields of oral implantolo

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