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Khalaf R, Cuffari C. Colonic Angioectasia in an Adolescent Boy with Hoyeraal-Hreidarsson on Long-Term Anabolic Steroid Therapy. Pediatr Gastroenterol Hepatol Nutr. 2018;21(1):68-71doi: 10.5223/pghn.2018.21.1.68.
Khalaf, R., & Cuffari, C. (2018). Colonic Angioectasia in an Adolescent Boy with Hoyeraal-Hreidarsson on Long-Term Anabolic Steroid Therapy. Pediatric gastroenterology, hepatology & nutrition, 21(1), 68-71. https://doi.org/10.5223/pghn.2018.21.1.68
Khalaf, Racha, and Cuffari, Carmen. "Colonic Angioectasia in an Adolescent Boy with Hoyeraal-Hreidarsson on Long-Term Anabolic Steroid Therapy." Pediatric gastroenterology, hepatology & nutrition vol. 21,1 (2018): 68-71. doi: https://doi.org/10.5223/pghn.2018.21.1.68
Khalaf R, Cuffari C. Colonic Angioectasia in an Adolescent Boy with Hoyeraal-Hreidarsson on Long-Term Anabolic Steroid Therapy. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):68-71. doi: 10.5223/pghn.2018.21.1.68. Epub 2018 Jan 12. PMID: 29383307; PMCID: PMC5788953.
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Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):68-71. doi: 10.5223/pghn.2018.21.1.68. Epub 2018 Jan 12.

Colonic Angioectasia in an Adolescent Boy with Hoyeraal-Hreidarsson on Long-Term Anabolic Steroid Therapy.

Pediatric gastroenterology, hepatology & nutrition

Racha Khalaf, Carmen Cuffari

Affiliations

  1. Department of Pediatrics, Johns Hopkins All Children's Hospital, The Johns Hopkins University School of Medicine, St. Petersburg, FL, USA.
  2. Division of Pediatric Gastroenterology, The Johns Hopkins Hospital, Baltimore, MD, USA.

PMID: 29383307 PMCID: PMC5788953 DOI: 10.5223/pghn.2018.21.1.68

Abstract

Androgen therapy has proven efficacy in treating patients with bone marrow failure who are not candidates for bone marrow transplantation. Herein, we report on a case of colonic angioectasia secondary to oxymetholone use in an adolescent patient with Hoyeraal-Hreidarsson syndrome (HHS). A 13-year-old Caucasian male with HHS characterized by cerebellar hypoplasia, developmental delay, microcephaly, esophageal strictures and myelodysplasia presented with severe hematochezia from colonic angioectasia secondary to long-term oxymetholone therapy. These vascular lesions resolved spontaneously once this anabolic steroid was discontinued. While androgen therapy is often recommended for certain anemias and myelodysplastic syndromes, clinicians should be aware of the potential complication in developing these perceived uncommon colonic angioectasias. Moreover, pediatric gastroenterologists should familiarize themselves in identifying these vascular lesions by colonoscopy, especially among the high risk groups on long-term anabolic steroid therapy.

Keywords: Angioectasia; Colon; Hoyeraal-Hreidarsson syndrome; Testosterone congeners

References

  1. Eur J Pediatr. 1997 Jan;156(1):80-1 - PubMed
  2. Br J Haematol. 2013 Sep;162(6):854-6 - PubMed
  3. Br J Haematol. 2015 Aug;170(4):457-71 - PubMed
  4. Blood Rev. 2010 May;24(3):101-22 - PubMed
  5. Dig Dis Sci. 1993 Jan;38(1):181-4 - PubMed
  6. Clin Ther. 2001 Jun;23(6):789-801; discussion 771 - PubMed
  7. J Urol. 1986 Jan;135(1):44-6 - PubMed
  8. Br J Haematol. 2014 May;165(3):349-57 - PubMed

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