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Altmayer NC, Galata V, Warschburger N, et al. Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts. Oncotarget. 2017;9(2):1803-1812doi: 10.18632/oncotarget.22804.
Altmayer, N. C., Galata, V., Warschburger, N., Keller, A., Meese, E., & Fischer, U. (2018). Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts. Oncotarget, 9(2), 1803-1812. https://doi.org/10.18632/oncotarget.22804
Altmayer, Nora Corinna, et al. "Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts." Oncotarget vol. 9,2 (2018): 1803-1812. doi: https://doi.org/10.18632/oncotarget.22804
Altmayer NC, Galata V, Warschburger N, Keller A, Meese E, Fischer U. Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts. Oncotarget. 2017 Dec 01;9(2):1803-1812. doi: 10.18632/oncotarget.22804. eCollection 2018 Jan 05. PMID: 29416732; PMCID: PMC5788600.
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Oncotarget. 2017 Dec 01;9(2):1803-1812. doi: 10.18632/oncotarget.22804. eCollection 2018 Jan 05.

Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts.

Oncotarget

Nora Corinna Altmayer, Valentina Galata, Nadine Warschburger, Andreas Keller, Eckart Meese, Ulrike Fischer

Affiliations

  1. Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.
  2. Chair of Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.

PMID: 29416732 PMCID: PMC5788600 DOI: 10.18632/oncotarget.22804

Abstract

Gene amplifications are an attribute of tumor cells and have for long time been overlooked in normal cells. A growing number of investigations describe gene amplifications in normal mammalian cells during development and differentiation. Possibly, tumor cells have rescued the gene amplification mechanism as a physiological attribute of stem cells. Here, we investigated human mesenchymal stem cells (hMSCs) for gene amplification using array-CGH, single cell fluorescence

Keywords: CDK4; MDM2; adipocyte; gene amplification; osteoblast

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interests.

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