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Kabir A, Zendehdel R, Tayefeh-Rahimian R. Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis. Iran J Public Health. 2018;47(2):148-155
Kabir, A., Zendehdel, R., & Tayefeh-Rahimian, R. (2018). Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis. Iranian journal of public health, 47(2), 148-155.
Kabir, Ali, et al. "Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis." Iranian journal of public health vol. 47,2 (2018): 148-155.
Kabir A, Zendehdel R, Tayefeh-Rahimian R. Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis. Iran J Public Health. 2018 Feb;47(2):148-155. PMID: 29445624; PMCID: PMC5810377.
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Iran J Public Health. 2018 Feb;47(2):148-155.

Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis.

Iranian journal of public health

Ali Kabir, Rezvan Zendehdel, Raana Tayefeh-Rahimian

Affiliations

  1. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
  2. Dept. of Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Dept. of Occupational Health Engineering, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 29445624 PMCID: PMC5810377

Abstract

BACKGROUND: In pesticide exposure groups such as farmers, the risk of prostate cancer was increased, although the report of the cause of evidence is limited. We selected chlorophenol compounds as an important group of the contaminated pesticide with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). This meta-analysis, the risk of death from prostate cancer was analyzed.

METHODS: PubMed, Scopus, Scholar Google and web of Sciences until 2016 were searched. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were obtained from the studies. We tested statistical heterogeneity with Cochrane Q test and I2 index. Egger test was used for evaluating publication bias. Random or fixed-effects models and meta-regression were also used in our analysis. Moreover, Cochrane tool was used to assess the risk of bias.

RESULTS: Five available papers consist of 28706 exposed populations were assessed. Overall standardized mortality rate as combined result of prostate cancer risk from the fixed model was 1.2 (95% confidence interval (CI) 1.02 to 1.42,

CONCLUSION: A contaminated pesticide with dioxins between other pesticides is an important risk factor for prostate cancers.

Keywords: Dioxin; Meta-analysis; Pesticides; Prostatic neoplasm

Conflict of interest statement

Conflict of Interests The authors declare that there is no conflict of interest.

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