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Hong JW, Noh JH, Kim DJ. Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population. Endocrinol Metab (Seoul). 2018;33(1):79-87doi: 10.3803/EnM.2018.33.1.79.
Hong, J. W., Noh, J. H., & Kim, D. J. (2018). Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population. Endocrinology and metabolism (Seoul, Korea), 33(1), 79-87. https://doi.org/10.3803/EnM.2018.33.1.79
Hong, Jae Won, et al. "Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population." Endocrinology and metabolism (Seoul, Korea) vol. 33,1 (2018): 79-87. doi: https://doi.org/10.3803/EnM.2018.33.1.79
Hong JW, Noh JH, Kim DJ. Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population. Endocrinol Metab (Seoul). 2018 Mar;33(1):79-87. doi: 10.3803/EnM.2018.33.1.79. Epub 2018 Jan 30. PMID: 29388402; PMCID: PMC5874199.
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Endocrinol Metab (Seoul). 2018 Mar;33(1):79-87. doi: 10.3803/EnM.2018.33.1.79. Epub 2018 Jan 30.

Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population.

Endocrinology and metabolism (Seoul, Korea)

Jae Won Hong, Jung Hyun Noh, Dong Jun Kim

Affiliations

  1. Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
  2. Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. [email protected].

PMID: 29388402 PMCID: PMC5874199 DOI: 10.3803/EnM.2018.33.1.79

Abstract

BACKGROUND: We examined whether white blood cell (WBC) count levels within normal range, could be associated with hemoglobin A1c (HbA1c) levels.

METHODS: Among the 11,472 people (≥19 years of age) who participated in the 2011 to 2012 Korea National Health and Nutrition Examination, subjects with chronic disease or illness, including 807 patients with diabetes currently taking anti-diabetic medications and/or 1,149 subjects with WBC levels <4,000 or >10,000/μL were excluded.

RESULTS: Overall, adjusted HbA1c levels increased across the WBC quartiles (5.55%±0.01%, 5.58%±0.01%, 5.60%±0.01%, and 5.65%±0.01%, P<0.001) after adjusting for confounding factors, such as age, gender, fasting plasma glucose, college graduation, smoking history, waist circumference, presence of hypertension, serum total cholesterol, serum triglyceride, and presence of anemia. The adjusted proportions (%) of HbA1c levels of ≥5.7%, ≥6.1%, and ≥6.5% showed significant increases across WBC quartiles (P<0.001, P=0.002, and P=0.022, respectively). Logistic regression analyses of WBC quartiles for the risk of HbA1c levels of ≥5.7%, ≥6.1%, and ≥6.5%, using the variables above as covariates, showed that the odds ratios of the fourth quartile of WBCs were 1.59 (95% confidence interval [CI], 1.35 to 1.89; P<0.001), 1.78 (95% CI, 1.31 to 2.42; P<0.001), and 2.03 (95% CI, 1.13 to 3.64; P=0.018), using the first quartile of WBCs as the reference.

CONCLUSION: HbA1c levels were positively associated with WBC levels within normal range in a general adult population.

Copyright © 2018 Korean Endocrine Society.

Keywords: Diabetes; Fasting plasma glucose; Glycated hemoglobin A; Leukocyte count

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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