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Viterbo VS, Lopez BIM, Kang H, et al. Genome wide association study of fatty acid composition in Duroc swine. Asian-Australas J Anim Sci. 2018;31(8):1127-1133doi: 10.5713/ajas.17.0779.
Viterbo, V. S., Lopez, B. I. M., Kang, H., Kim, H., Song, C. W., & Seo, K. S. (2018). Genome wide association study of fatty acid composition in Duroc swine. Asian-Australasian journal of animal sciences, 31(8), 1127-1133. https://doi.org/10.5713/ajas.17.0779
Viterbo, Vanessa S, et al. "Genome wide association study of fatty acid composition in Duroc swine." Asian-Australasian journal of animal sciences vol. 31,8 (2018): 1127-1133. doi: https://doi.org/10.5713/ajas.17.0779
Viterbo VS, Lopez BIM, Kang H, Kim H, Song CW, Seo KS. Genome wide association study of fatty acid composition in Duroc swine. Asian-Australas J Anim Sci. 2018 Aug;31(8):1127-1133. doi: 10.5713/ajas.17.0779. Epub 2018 Mar 02. PMID: 29514447; PMCID: PMC6043425.
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Asian-Australas J Anim Sci. 2018 Aug;31(8):1127-1133. doi: 10.5713/ajas.17.0779. Epub 2018 Mar 02.

Genome wide association study of fatty acid composition in Duroc swine.

Asian-Australasian journal of animal sciences

Vanessa S Viterbo, Bryan Irvine M Lopez, Hyunsung Kang, Hoonseop Kim, Choul-Won Song, Kang Seok Seo

Affiliations

  1. Department of Animal Science and Technology, Sunchon National University, Suncheon 57922, Korea.
  2. Department of Animal Science, College of Agriculture, Central Luzon State University, Science City of Mu?oz, 3120, Philippines.

PMID: 29514447 PMCID: PMC6043425 DOI: 10.5713/ajas.17.0779

Abstract

OBJECTIVE: Genome wide association study was conducted to identify and validate candidate genes associated with fatty acid composition of pork.

METHODS: A total of 480 purebreed Duroc pigs were genotyped using IlluminaPorcine60k bead chips while the association test was implemented following genome-wide rapid association using Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approach.

RESULTS: A total of 25, 29, and 16 single nucleotide polymorphisms (SNPs) were significantly associated with stearic (18:0), oleic (18:1) and saturated fatty acids (SFA), respectively. Genome wide significant variants were located on the same region of swine chromosome 14 (SSC14) that spanned from 120 to 124 Mb. Top SNP ALGA008191 was located at 5 kb near the stearoyl-CoA desaturase (SCD) gene. This gene is directly involved in desaturation of stearic acid into oleic acid. General relationship of significant SNPs showed high linkage disequilibrium thus genome-wide signals was attributed to SCD gene. However, understanding the role of other genes like elongation of very long chain fatty acids-3 (ELOVL3) located on this chromosomal segment might help in further understanding of metabolism and biosynthesis of fatty acids.

CONCLUSION: Overall, this study provides evidence that validates SCD gene as strong candidate gene associated with fatty acid composition in Duroc pigs. Moreover, this study confirms significant SNPs near ELOVL3 gene.

Keywords: Fatty Acid; Genome Wide Association Study (GWAS); Stearoyl-CoA Desaturase (SCD) Gene; Duroc

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