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Evol Bioinform Online. 2018 Feb 05;14:1176934318754878. doi: 10.1177/1176934318754878. eCollection 2018.

Genetic Diversity and Functional Analysis of Sigma Factors in .

Evolutionary bioinformatics online

Farah Nazir, Muhammad Ibrahim, Ghunva Zaman, Annam Hussain, Asma Muhammad Yar, Zhu Bo

Affiliations

  1. Key Laboratory of Urban Agriculture by Ministry of Agriculture of China, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
  2. Genomics and Computational Biology Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Sahiwal, Pakistan.
  3. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, China.

PMID: 29472760 PMCID: PMC5808824 DOI: 10.1177/1176934318754878

Abstract

Sigma factors are bacterial transcription factors that bind the core RNA polymerase and direct transcription initiation at a specific promoter site. These specialized sigma factors bind the promoters of genes appropriate to the environmental conditions and selectively increase the transcription of those genes. Here, we attempt to identify sigma factors in 5 genomes belonging to the

Keywords: Sigma factor; genomics; in silico analysis of the Enterobacter cloacae complex; nosocomial pathogen

Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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