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Malinowska M, Tokarz-Deptuła B, Deptuła W. Butyrophilins: an important new element of resistance. Cent Eur J Immunol. 2017;42(4):399-403doi: 10.5114/ceji.2017.72806.
Malinowska, M., Tokarz-Deptuła, B., & Deptuła, W. (2017). Butyrophilins: an important new element of resistance. Central-European journal of immunology, 42(4), 399-403. https://doi.org/10.5114/ceji.2017.72806
Malinowska, Magdalena, et al. "Butyrophilins: an important new element of resistance." Central-European journal of immunology vol. 42,4 (2017): 399-403. doi: https://doi.org/10.5114/ceji.2017.72806
Malinowska M, Tokarz-Deptuła B, Deptuła W. Butyrophilins: an important new element of resistance. Cent Eur J Immunol. 2017;42(4):399-403. doi: 10.5114/ceji.2017.72806. Epub 2017 Dec 30. PMID: 29472819; PMCID: PMC5820976.
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Cent Eur J Immunol. 2017;42(4):399-403. doi: 10.5114/ceji.2017.72806. Epub 2017 Dec 30.

Butyrophilins: an important new element of resistance.

Central-European journal of immunology

Magdalena Malinowska, Beata Tokarz-Deptuła, Wiesław Deptuła

Affiliations

  1. Szczecin University, Szczecin, Poland.

PMID: 29472819 PMCID: PMC5820976 DOI: 10.5114/ceji.2017.72806

Abstract

Butyrophilins belonging to the immunoglobulin superfamily are new immune system regulators because they are present on lymphocytes, dendritic cells, monocytes, macrophages, neutrophils and eosinophils, and they exert a stimulatory and (or) inhibitory effect on them. The role of butyrophilins is associated and results from their similarity to the regulatory B7 protein family involved in the modulation of immune phenomena. Butyrophilins are glycoproteins built of two extracellular immunoglobulin domains, stabilized with disulfide bonds: constant IgC, and variable IgV and a transmembrane region. Most of these proteins contain a conserved domain encoded by a single exon - B30.2, also referred to as PRYSPRY. In humans, the family of butyrophilins includes 7 butyrophilin proteins, 5 butyrophilin-like proteins and the SKINT-like factor. Butyrophilins have been also demonstrated to play a role in various infections, e.g. tuberculosis or diseases that include sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis, genetic metabolic diseases, ulcerative colitis, cancer and kidney disease.

Keywords: butyrophilin-like protein; butyrophilins; immune system

Conflict of interest statement

The authors declare no conflict of interest.

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