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Rabello DDA, Ferreira VDDS, Berzoti-Coelho MG, et al. . Cancer Cell Int. 2018;18:26doi: 10.1186/s12935-018-0523-1.
Rabello, D. D. A., Ferreira, V. D. D. S., Berzoti-Coelho, M. G., Burin, S. M., Magro, C. L., Cacemiro, M. D. C., Simões, B. P., Saldanha-Araujo, F., de Castro, F. A., & Pittella-Silva, F. (2018). . Cancer cell international, 1826. https://doi.org/10.1186/s12935-018-0523-1
Rabello, Doralina do Amaral, et al. "." Cancer cell international vol. 18 (2018): 26. doi: https://doi.org/10.1186/s12935-018-0523-1
Rabello DDA, Ferreira VDDS, Berzoti-Coelho MG, Burin SM, Magro CL, Cacemiro MDC, Simões BP, Saldanha-Araujo F, de Castro FA, Pittella-Silva F. . Cancer Cell Int. 2018 Feb 20;18:26. doi: 10.1186/s12935-018-0523-1. eCollection 2018. PMID: 29483845; PMCID: PMC5819641.
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Cancer Cell Int. 2018 Feb 20;18:26. doi: 10.1186/s12935-018-0523-1. eCollection 2018.

[No title available]

Cancer cell international

Doralina do Amaral Rabello, Vivian D'Afonseca da Silva Ferreira, Maria Gabriela Berzoti-Coelho, Sandra Mara Burin, Cíntia Leticia Magro, Maira da Costa Cacemiro, Belinda Pinto Simões, Felipe Saldanha-Araujo, Fabíola Attié de Castro, Fabio Pittella-Silva

Affiliations

  1. 1Laboratory of Molecular Pathology of Cancer, Faculty of Health Sciences and Medicine, University of Brasilia, Brasília, DF Brazil.
  2. 2Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP Brazil.
  3. 3Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP Brazil.
  4. 4Laboratory of Molecular Pharmacology, Faculty of Health Sciences, University of Brasilia, Brasília, DF Brazil.

PMID: 29483845 PMCID: PMC5819641 DOI: 10.1186/s12935-018-0523-1

Abstract

BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates the

METHODS: Here we investigated the expression profile of both genes in CML patients in different stages of the disease, in patients showing different responses to therapy with IM and in non-neoplastic control samples. Imatinib sensitive and resistant CML cell lines were also used to investigate whether treatment with other tyrosine kinase inhibitors interfered in their expression.

RESULTS: In patients, both methyltransferases were either upregulated or with basal expression level during the chronic phase compared to controls. Interestingly,

CONCLUSION: Our results established a new association between

Keywords: Chronic myeloid leukemia; Epigenetic; Genetic alterations; Lysine methyltransferase; MLL2/KMT2D; MLL3/KMT2C

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