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Rey-Martinez J, Batuecas-Caletrio A, Matiño E, et al. Mathematical Methods for Measuring the Visually Enhanced Vestibulo-Ocular Reflex and Preliminary Results from Healthy Subjects and Patient Groups. Front Neurol. 2018;9:69doi: 10.3389/fneur.2018.00069.
Rey-Martinez, J., Batuecas-Caletrio, A., Matiño, E., Trinidad-Ruiz, G., Altuna, X., & Perez-Fernandez, N. (2018). Mathematical Methods for Measuring the Visually Enhanced Vestibulo-Ocular Reflex and Preliminary Results from Healthy Subjects and Patient Groups. Frontiers in neurology, 969. https://doi.org/10.3389/fneur.2018.00069
Rey-Martinez, Jorge, et al. "Mathematical Methods for Measuring the Visually Enhanced Vestibulo-Ocular Reflex and Preliminary Results from Healthy Subjects and Patient Groups." Frontiers in neurology vol. 9 (2018): 69. doi: https://doi.org/10.3389/fneur.2018.00069
Rey-Martinez J, Batuecas-Caletrio A, Matiño E, Trinidad-Ruiz G, Altuna X, Perez-Fernandez N. Mathematical Methods for Measuring the Visually Enhanced Vestibulo-Ocular Reflex and Preliminary Results from Healthy Subjects and Patient Groups. Front Neurol. 2018 Feb 12;9:69. doi: 10.3389/fneur.2018.00069. eCollection 2018. PMID: 29483893; PMCID: PMC5816338.
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Front Neurol. 2018 Feb 12;9:69. doi: 10.3389/fneur.2018.00069. eCollection 2018.

Mathematical Methods for Measuring the Visually Enhanced Vestibulo-Ocular Reflex and Preliminary Results from Healthy Subjects and Patient Groups.

Frontiers in neurology

Jorge Rey-Martinez, Angel Batuecas-Caletrio, Eusebi Matiño, Gabriel Trinidad-Ruiz, Xabier Altuna, Nicolas Perez-Fernandez

Affiliations

  1. Otorhinolaringology, Hospital Universitario Donostia, San Sebastian, Spain.
  2. Complejo Hospitalario de Salamanca, Salamanca, Spain.
  3. Hospital General de Catalunya, Barcelona, Spain.
  4. University Hospital of Badajoz, Badajoz, Spain.
  5. Clínica Universidad de Navarra, Madrid, Spain.

PMID: 29483893 PMCID: PMC5816338 DOI: 10.3389/fneur.2018.00069

Abstract

BACKGROUND: Visually enhanced vestibulo-ocular reflex (VVOR) is a well-known bedside clinical test to evaluate visuo-vestibular interaction, with clinical applications in patients with neurological and vestibular dysfunctions. Owing to recently developed diagnostic technologies, the possibility to perform an easy and objective measurement of the VVOR has increased, but there is a lack of computational methods designed to obtain an objective VVOR measurement.

OBJECTIVES: To develop a method for the assessment of the VVOR to obtain a gain value that compares head and eye velocities and to test this method in patients and healthy subjects.

METHODS: Two computational methods were developed to measure the VVOR test responses: the first method was based on the area under curve of head and eye velocity plots and the second method was based on the slope of the linear regression obtained for head and eye velocity data. VVOR gain and vestibulo-ocular reflex (VOR) gain were analyzed with the data obtained from 35 subjects divided into four groups: healthy (

RESULTS: Intra-class correlation index for the two developed VVOR analysis methods was 0.99. Statistical differences were obtained by analysis of variance statistical method, comparing the healthy group (VVOR mean gain of 1 ± 0) with all other groups. The CANVAS group exhibited (VVOR mean gain of 0.4 ± 0.1) differences when compared to all other groups. VVOR mean gain for the vestibular bilateral group was 0.8 ± 0.1. VVOR mean gain in the unilateral group was 0.6 ± 0.1, with a Pearson's correlation of 0.52 obtained when VVOR gain was compared to the VOR gain of the operated side.

CONCLUSION: Two computational methods to measure the gain of VVOR were successfully developed. The VVOR gain values appear to objectively characterize the VVOR alteration observed in CANVAS patients, and also distinguish between healthy subjects and patients with some vestibular disorders.

Keywords: CANVAS; Visually enhanced VOR; algorithms; dessaccade; gain; vestibular schwannoma; vestibulo–ocular reflex; video head impulse test; visual–vestibular interaction

References

  1. Brain. 1991 Feb;114 ( Pt 1A):1-11 - PubMed
  2. Vision Res. 1997 Jun;37(12):1643-52 - PubMed
  3. Arch Otolaryngol Head Neck Surg. 2002 Sep;128(9):1044-54 - PubMed
  4. Neurology. 2009 Oct 6;73(14):1134-41 - PubMed
  5. Vision Res. 1985;25(4):561-3 - PubMed
  6. Brain. 2004 Feb;127(Pt 2):280-93 - PubMed
  7. Lancet. 1986 Feb 8;1(8476):307-10 - PubMed
  8. Ann N Y Acad Sci. 2009 May;1164:486-91 - PubMed
  9. Front Neurol. 2015 Jul 08;6:154 - PubMed
  10. Neuroreport. 2004 Dec 3;15(17):2617-20 - PubMed
  11. Otol Neurotol. 2015 Mar;36(3):466-71 - PubMed
  12. Brain Struct Funct. 2017 Jul;222(5):2329-2343 - PubMed
  13. Neurology. 2013 Oct 29;81(18):1642-3 - PubMed
  14. Audiol Neurootol. 2015;20(1):39-50 - PubMed
  15. PLoS One. 2013 Apr 22;8(4):e61488 - PubMed
  16. J Vestib Res. 1994 May-Jun;4(3):245-9 - PubMed
  17. Neurol Clin Pract. 2016 Feb;6(1):61-68 - PubMed
  18. Arch Neurol. 1988 Jul;45(7):737-9 - PubMed
  19. Can Assoc Radiol J. 2003 Apr;54(2):80-6 - PubMed
  20. Exp Brain Res. 1999 Jul;127(1):54-66 - PubMed
  21. Biol Cybern. 1986;55(1):43-57 - PubMed
  22. Clin Neurophysiol. 2016 Aug;127(8):2791-801 - PubMed
  23. Int J Pediatr Otorhinolaryngol. 2008 Jan;72(1):1-7 - PubMed
  24. Eur Arch Otorhinolaryngol. 2017 Mar;274(3):1215-1222 - PubMed
  25. Handb Clin Neurol. 2016;137:1-16 - PubMed
  26. Brain Res. 1986 May 14;373(1-2):399-408 - PubMed
  27. Otolaryngol Head Neck Surg. 1995 Jan;112(1):16-35 - PubMed
  28. J Neurol. 2017 Jan;264(1):188-203 - PubMed
  29. Laryngoscope. 2006 Sep;116(9):1577-9 - PubMed
  30. Rev Neurol (Paris). 2012 Oct;168(10):710-9 - PubMed
  31. Exp Brain Res. 1994;98(2):355-72 - PubMed

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