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Front Immunol. 2018 Jan 26;8:2010. doi: 10.3389/fimmu.2017.02010. eCollection 2017.

Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy .

Frontiers in immunology

Alex Olvera, Javier P Martinez, Maria Casadellà, Anuska Llano, Míriam Rosás, Beatriz Mothe, Marta Ruiz-Riol, Gemma Arsequell, Gregorio Valencia, Marc Noguera-Julian, Roger Paredes, Andreas Meyerhans, Christian Brander

Affiliations

  1. IrsiCaixa - AIDS Research Institute, Badalona, Barcelona, Spain.
  2. Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Barcelona, Spain.
  3. Infection Biology Group, Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain.
  4. Unitat VIH, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
  5. Institut de Química Avançada de Catalunya (IQAC-CSIC), Barcelona, Spain.
  6. Universitat Autonoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
  7. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

PMID: 29472913 PMCID: PMC5810283 DOI: 10.3389/fimmu.2017.02010

Abstract

Glycosylation of host and viral proteins is an important posttranslational modification needed to ensure correct function of glycoproteins. For this reason, we asked whether inhibition of O-glycosylation during human immunodeficiency virus (HIV)

Keywords: O-glycosylation; benzyl-2-acetamido-2-deoxy-α-d-galactopyranoside; human immunodeficiency virus-1; infectivity; replication; viral outgrowth

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