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Ha J, Lee J, Jo K, et al. Sex differences in risk factors for subclinical hypothyroidism. Endocr Connect. 2018;7(4):511-522doi: 10.1530/EC-18-0023.
Ha, J., Lee, J., Jo, K., Lim, D. J., Kang, M. I., Cha, B. Y., & Kim, M. H. (2018). Sex differences in risk factors for subclinical hypothyroidism. Endocrine connections, 7(4), 511-522. https://doi.org/10.1530/EC-18-0023
Ha, Jeonghoon, et al. "Sex differences in risk factors for subclinical hypothyroidism." Endocrine connections vol. 7,4 (2018): 511-522. doi: https://doi.org/10.1530/EC-18-0023
Ha J, Lee J, Jo K, Lim DJ, Kang MI, Cha BY, Kim MH. Sex differences in risk factors for subclinical hypothyroidism. Endocr Connect. 2018 Apr;7(4):511-522. doi: 10.1530/EC-18-0023. Epub 2018 Mar 07. PMID: 29514897; PMCID: PMC5881431.
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Endocr Connect. 2018 Apr;7(4):511-522. doi: 10.1530/EC-18-0023. Epub 2018 Mar 07.

Sex differences in risk factors for subclinical hypothyroidism.

Endocrine connections

Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Dong-Jun Lim, Moo Il Kang, Bong Yun Cha, Min-Hee Kim

Affiliations

  1. Division of Endocrinology and MetabolismDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  2. Division of Endocrinology and MetabolismDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea [email protected].

PMID: 29514897 PMCID: PMC5881431 DOI: 10.1530/EC-18-0023

Abstract

OBJECTIVE: To investigate the prevalence of subclinical hypothyroidism (SCH) in Korean adults and identify the risk factors for the occurrence of SCH by sex.

DESIGN AND METHODS: This study used data from the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI), a cross-sectional, nationally representative survey, which comprises a health interview survey, a health examination survey and a nutrition survey. To examine SCH, the reference range of thyroid-stimulating hormone (TSH) was defined using both the range provided by the test kit manufacturer (SCH-M) and a population-based range (SCH-P). We investigated the prevalence of SCH and its risk factors by sex using both reference ranges.

RESULTS: The prevalence of SCH in Koreans according to SCH-M (0.35-5.5 µIU/mL) was 5.6%, and 3.3% with SCH-P (0.62-6.68 µIU/mL). For men, smoking significantly reduced the incidence of SCH, positive anti-thyroid peroxidase antibody (TPOAb) significantly increased the risk of SCH, and in an adjusted model, the risk of SCH in all quartiles increased as the urine iodine creatinine ratio (UICR) quartile increased. For women, positive TPOAb was confirmed as a risk factor for SCH, as was the highest UICR quartile. Furthermore, the odds ratio for SCH in urban vs rural residence was 1.78.

CONCLUSIONS: The prevalence rates of SCH were similar to those reported in the literature and previously known risk factors were confirmed using both TSH reference ranges. The notable findings from this study are that the increased risk of SCH with increased iodine intake was more marked in men than in women and that residential area may be a risk factor for SCH in women.

© 2018 The authors.

Keywords: prevalence; sex differences; subclinical hypothyroidism; urine iodine

References

  1. Clin Endocrinol (Oxf). 2016 Jun;84(6):878-81 - PubMed
  2. Clin Endocrinol (Oxf). 2003 Sep;59(3):396-401 - PubMed
  3. J Prenat Med. 2012 Oct;6(4):64-71 - PubMed
  4. Diabetes Metab J. 2017 Feb;41(1):38-50 - PubMed
  5. J Clin Endocrinol Metab. 1999 Feb;84(2):561-6 - PubMed
  6. Eur J Endocrinol. 2000 Nov;143(5):639-47 - PubMed
  7. Semin Reprod Med. 2016 Nov;34(6):323-330 - PubMed
  8. Eur J Clin Nutr. 2015 Apr;69(4):425-30 - PubMed
  9. Thyroid. 2003 Jan;13(1):3-126 - PubMed
  10. BMC Public Health. 2017 Jan 13;17 (1):71 - PubMed
  11. Am J Kidney Dis. 2014 May;63(5):713-35 - PubMed
  12. Arch Intern Med. 2000 Feb 28;160(4):526-34 - PubMed
  13. Endocrinol Metab (Seoul). 2017 Mar;32(1):106-114 - PubMed
  14. J Clin Endocrinol Metab. 1998 Mar;83(3):765-9 - PubMed
  15. J Clin Endocrinol Metab. 2002 Feb;87(2):489-99 - PubMed
  16. Endocrinol Metab (Seoul). 2014 Mar;29(1):20-9 - PubMed
  17. Mayo Clin Proc. 2009;84(1):65-71 - PubMed
  18. Arch Med Res. 2006 May;37(4):511-6 - PubMed
  19. N Engl J Med. 2006 Jun 29;354(26):2783-93 - PubMed
  20. Clin Endocrinol (Oxf). 1995 Jul;43(1):55-68 - PubMed
  21. Exp Mol Pathol. 1986 Jun;44(3):259-71 - PubMed
  22. Endocrinology. 1964 May;74:680-8 - PubMed
  23. J Clin Endocrinol Metab. 1994 Feb;78(2):393-7 - PubMed
  24. Steroids. 2006 Aug;71(8):653-9 - PubMed
  25. Korean J Intern Med. 2003 Sep;18(3):146-53 - PubMed
  26. Clin Endocrinol (Oxf). 2003 Jan;58(1):36-42 - PubMed
  27. Nutr Diabetes. 2015 Apr 27;5:e149 - PubMed
  28. Endocrinology. 1999 Dec;140(12):5705-11 - PubMed
  29. Indian J Endocrinol Metab. 2010 Jan;14(1):13-7 - PubMed
  30. Clin Endocrinol (Oxf). 1977 Dec;7(6):481-93 - PubMed

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