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Katoh D, Hongo K, Ito K, et al. Corticosteroids increase intracellular free sodium ion concentration via glucocorticoid receptor pathway in cultured neonatal rat cardiomyocytes. Int J Cardiol Heart Vessel. 2014;3:49-56doi: 10.1016/j.ijchv.2014.03.001.
Katoh, D., Hongo, K., Ito, K., Yoshino, T., Kayama, Y., Kawai, M., Date, T., Yoshimura, M., & Youngs, P. (2014). Corticosteroids increase intracellular free sodium ion concentration via glucocorticoid receptor pathway in cultured neonatal rat cardiomyocytes. International journal of cardiology. Heart & vessels, 349-56. https://doi.org/10.1016/j.ijchv.2014.03.001
Katoh, Daisuke, et al. "Corticosteroids increase intracellular free sodium ion concentration via glucocorticoid receptor pathway in cultured neonatal rat cardiomyocytes." International journal of cardiology. Heart & vessels vol. 3 (2014): 49-56. doi: https://doi.org/10.1016/j.ijchv.2014.03.001
Katoh D, Hongo K, Ito K, Yoshino T, Kayama Y, Kawai M, Date T, Yoshimura M, Youngs P. Corticosteroids increase intracellular free sodium ion concentration via glucocorticoid receptor pathway in cultured neonatal rat cardiomyocytes. Int J Cardiol Heart Vessel. 2014 Mar 13;3:49-56. doi: 10.1016/j.ijchv.2014.03.001. eCollection 2014 Jun. PMID: 29450170; PMCID: PMC5801272.
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Int J Cardiol Heart Vessel. 2014 Mar 13;3:49-56. doi: 10.1016/j.ijchv.2014.03.001. eCollection 2014 Jun.

Corticosteroids increase intracellular free sodium ion concentration via glucocorticoid receptor pathway in cultured neonatal rat cardiomyocytes.

International journal of cardiology. Heart & vessels

Daisuke Katoh, Kenichi Hongo, Keiichi Ito, Takuya Yoshino, Yosuke Kayama, Makoto Kawai, Taro Date, Michihiro Yoshimura, Youngs

Affiliations

  1. Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.

PMID: 29450170 PMCID: PMC5801272 DOI: 10.1016/j.ijchv.2014.03.001

Abstract

BACKGROUND: Glucocorticoids as well as mineralocorticoid have been shown to play essential roles in the regulation of electrical and mechanical activities in cardiomyocytes. Excess of these hormones is an independent risk factor for cardiovascular disease. Intracellular sodium ([Na

METHODS AND RESULTS: We herein demonstrate the quantitative estimation of [Na

CONCLUSIONS: The physiological concentration of glucocorticoids increases [Na

Keywords: Cardiomyocytes; Corticosteroids; Glucocorticoid receptor; Hypertrophy; Intracellular sodium

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