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Norouzinia F, Abbasi F, Dindarian S, et al. Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma. Turk J Urol. 2018;44(1):31-35doi: 10.5152/tud.2018.91455.
Norouzinia, F., Abbasi, F., Dindarian, S., Mohammadi, S., Meisami, F., Bagheri, M., & Mohammadi, H. (2018). Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma. Turkish journal of urology, 44(1), 31-35. https://doi.org/10.5152/tud.2018.91455
Norouzinia, Farahnaz, et al. "Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma." Turkish journal of urology vol. 44,1 (2018): 31-35. doi: https://doi.org/10.5152/tud.2018.91455
Norouzinia F, Abbasi F, Dindarian S, Mohammadi S, Meisami F, Bagheri M, Mohammadi H. Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma. Turk J Urol. 2018 Jan;44(1):31-35. doi: 10.5152/tud.2018.91455. Epub 2018 Jan 08. PMID: 29484224; PMCID: PMC5821279.
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Turk J Urol. 2018 Jan;44(1):31-35. doi: 10.5152/tud.2018.91455. Epub 2018 Jan 08.

Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma.

Turkish journal of urology

Farahnaz Norouzinia, Fariba Abbasi, Sina Dindarian, Sedra Mohammadi, Farid Meisami, Mahdi Bagheri, Hozan Mohammadi

Affiliations

  1. Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  2. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
  3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 29484224 PMCID: PMC5821279 DOI: 10.5152/tud.2018.91455

Abstract

OBJECTIVE: Renal cell carcinomas (RCCs) include about 2% of adult neoplasms and 90-95% of all renal tumors. Mostly, it is possible to distinguish RCC subtypes using hematoxylin-eosin staining. However, overlapping morphologic features cause some difficulties in making a precise diagnosis. In order to render an accurate diagnosis, additional methods such as immunohistochemical staining for c-kit have been recommended. In this study, we aimed to investigate c-kit gene expression in various subtypes of RCC.

MATERIAL AND METHODS: We reviewed 65 diagnosed RCC cases. Formalin- fixed, paraffin- embedded specimens were available for the cases. The expression of c-kit was evaluated using immunohistochemistry. The correlation between c-kit expression and clinicopathological parameters including patients' age and gender in addition to grade, stage, and size of the tumor were investigated.

RESULTS: Six cases of 39 clear cell types (15.4%), 8 of 13 papillary types (61.5%), 11 of 12 chromophobe types (91.7%), and no sarcomatoid type were positive for c-kit expression. Based on chi-square test results, there was a significant relationship between RCC subtypes and c-kit expression (p=0.001). There was no significant correlation between age, sex, grade, stage, and size of the tumor and c-kit expression.

CONCLUSION: The expression of c-kit in RCC may have diagnostic significance in subtypes of RCC especially papillary and chromophobe subtypes of RCC.

Keywords: C-kit; H&E staining; KIT; renal cell carcinoma

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

References

  1. Cancer Res. 1992 Nov 15;52(22):6139-43 - PubMed
  2. Arch Pathol Lab Med. 2007 Aug;131(8):1290-7 - PubMed
  3. Hematol Oncol Clin North Am. 2000 Jun;14(3):517-35 - PubMed
  4. CA Cancer J Clin. 2017 Jan;67(1):7-30 - PubMed
  5. Radiographics. 1997 Jul-Aug;17 (4):993-8 - PubMed
  6. Am J Surg Pathol. 1982 Oct;6(7):655-63 - PubMed
  7. Urol Clin North Am. 1999 Aug;26(3):643-60, viii - PubMed
  8. Anticancer Drugs. 2003 Apr;14(4):313-9 - PubMed
  9. BJU Int. 2005 Feb;95(3):315-8 - PubMed
  10. Cancer. 1993 Apr 1;71(7):2292-8 - PubMed
  11. Am J Clin Pathol. 2004 Jun;121(6):878-83 - PubMed
  12. Hum Pathol. 2002 May;33(5):484-95 - PubMed
  13. J Clin Pathol. 2004 May;57(5):463-6 - PubMed
  14. Virchows Arch. 2002 Oct;441(4):320-7 - PubMed
  15. Mod Pathol. 2004 Jun;17(6):611-6 - PubMed
  16. Eur Urol. 2016 Jul;70(1):93-105 - PubMed
  17. Histopathology. 2000 Mar;36(3):195-202 - PubMed
  18. BJU Int. 2000 Jul;86(1):20-7 - PubMed
  19. Urol Int. 1998;61(3):172-4 - PubMed
  20. Zhonghua Bing Li Xue Za Zhi. 2004 Apr;33(2):140-2 - PubMed
  21. J Cancer Res Clin Oncol. 2009 Feb;135(2):249-53 - PubMed
  22. Int J Biochem Cell Biol. 1999 Oct;31(10):1037-51 - PubMed
  23. Curr Probl Cancer. 1984 Nov;8(17):1-62 - PubMed
  24. J Egypt Natl Canc Inst. 2009 Jun;21(2):121-32 - PubMed
  25. Oncology. 2003;65(3):187-97 - PubMed
  26. Virchows Arch. 1994;424(2):135-41 - PubMed
  27. Cancer Res. 1991 May 1;51(9):2416-9 - PubMed
  28. Oncogene. 2003 Feb 13;22(6):847-52 - PubMed

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