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Sonvico F, Clementino A, Buttini F, et al. Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics. 2018;10(1)doi: 10.3390/pharmaceutics10010034.
Sonvico, F., Clementino, A., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S. (2018). Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics, 10(1), . https://doi.org/10.3390/pharmaceutics10010034
Sonvico, Fabio, et al. "Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting." Pharmaceutics vol. 10,1 (2018). doi: https://doi.org/10.3390/pharmaceutics10010034
Sonvico F, Clementino A, Buttini F, Colombo G, Pescina S, Stanisçuaski Guterres S, Raffin Pohlmann A, Nicoli S. Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics. 2018 Mar 15;10(1). doi: 10.3390/pharmaceutics10010034. PMID: 29543755; PMCID: PMC5874847.
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Pharmaceutics. 2018 Mar 15;10(1). doi: 10.3390/pharmaceutics10010034.

Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting.

Pharmaceutics

Fabio Sonvico, Adryana Clementino, Francesca Buttini, Gaia Colombo, Silvia Pescina, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Sara Nicoli

Affiliations

  1. Interdipartmental Center for Innovation in Health Products, BIOPHARMANET TEC, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  2. Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  3. Interdipartmental Center for Innovation in Health Products, BIOPHARMANET TEC, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  4. Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  5. Interdipartmental Center for Innovation in Health Products, BIOPHARMANET TEC, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  6. Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  7. Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy. [email protected].
  8. Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  9. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. [email protected].
  10. Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil. [email protected].
  11. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil. [email protected].
  12. Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil. [email protected].
  13. Interdipartmental Center for Innovation in Health Products, BIOPHARMANET TEC, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].
  14. Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy. [email protected].

PMID: 29543755 PMCID: PMC5874847 DOI: 10.3390/pharmaceutics10010034

Abstract

In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects. Recently, nasal administration of insulin showed promising results in clinical trials for the treatment of Alzheimer's disease. Nanomedicines could further contribute to making nose-to-brain delivery a reality. While not disregarding the need for devices enabling a formulation deposition in the nose's upper part, surface modification of nanomedicines appears the key strategy to optimize drug delivery from the nasal cavity to the brain. In this review, nanomedicine delivery based on particle engineering exploiting surface electrostatic charges, mucoadhesive polymers, or chemical moieties targeting the nasal epithelium will be discussed and critically evaluated in relation to nose-to-brain delivery.

Keywords: Alzheimer’s disease; CNS disorders; Parkinson’s disease; mucoadhesion; mucus-penetrating particles; nanoparticles; neurodegenerative diseases; nose-to-brain delivery; pharmaceutical nanotechnology; targeting

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. Curr Top Med Chem. 2015;15(4):356-68 - PubMed
  2. Eur J Pharm Biopharm. 2014 May;87(1):30-9 - PubMed
  3. J Neuroimmunol. 2013 May 15;258(1-2):32-40 - PubMed
  4. Int J Pharm. 2016 Nov 20;513(1-2):280-293 - PubMed
  5. Expert Opin Drug Deliv. 2013 Jul;10(7):957-72 - PubMed
  6. Pharm Res. 2012 Feb;29(2):546-58 - PubMed
  7. Mol Pharm. 2015 Aug 3;12(8):2755-66 - PubMed
  8. J Control Release. 2017 Sep 10;261:187-198 - PubMed
  9. Drugs R D. 2007;8(3):133-44 - PubMed
  10. ACS Nano. 2015 Sep 22;9(9):9217-27 - PubMed
  11. Int J Pharm. 2009 Sep 8;379(1):146-57 - PubMed
  12. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18355-60 - PubMed
  13. Eur J Pharm Biopharm. 2004 Sep;58(2):327-41 - PubMed
  14. J Neurooncol. 2014 Feb;116(3):437-46 - PubMed
  15. J Control Release. 2014 Oct 28;192:202-8 - PubMed
  16. Drug Deliv. 2015;22(7):931-9 - PubMed
  17. Int J Biol Macromol. 2018 Apr 1;109 :27-35 - PubMed
  18. Int J Pharm. 2017 Sep 15;530(1-2):1-11 - PubMed
  19. Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):13-38 - PubMed
  20. Biomaterials. 2013 Apr;34(13):3439-46 - PubMed
  21. Adv Drug Deliv Rev. 2012 May 15;64(7):640-65 - PubMed
  22. Drug Des Devel Ther. 2017 Jun 19;11:1815-1825 - PubMed
  23. Cell Mol Life Sci. 2005 Nov;62(22):2560-75 - PubMed
  24. J Pharm Sci. 2014 Feb;103(2):628-35 - PubMed
  25. Int J Pharm. 2007 Aug 1;340(1-2):207-15 - PubMed
  26. Drug Discov Today. 2002 Sep 15;7(18):967-75 - PubMed
  27. Adv Drug Deliv Rev. 2005 Nov 3;57(11):1640-65 - PubMed
  28. CNS Drug Rev. 2005 Winter;11(4):353-68 - PubMed
  29. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5675-9 - PubMed
  30. Ther Deliv. 2017 Jul;8(8):625-631 - PubMed
  31. Pharm Res. 2000 Jun;17(6):743-8 - PubMed
  32. J Microencapsul. 2017 Nov;34(7):644-658 - PubMed
  33. Colloids Surf B Biointerfaces. 2016 Nov 1;147:376-386 - PubMed
  34. Biomaterials. 2011 Dec;32(36):9888-98 - PubMed
  35. Int J Pharm. 2006 Jul 6;317(1):40-6 - PubMed
  36. Adv Drug Deliv Rev. 2009 Feb 27;61(2):75-85 - PubMed
  37. Drug Deliv. 2012 Jan;19(1):58-67 - PubMed
  38. Int J Pharm. 2017 Sep 15;530(1-2):195-200 - PubMed
  39. J Control Release. 2014 Sep 10;189:133-40 - PubMed
  40. Nanoscale. 2015 Mar 7;7(9):4199-210 - PubMed
  41. Int J Biol Macromol. 2013 Oct;61:189-95 - PubMed
  42. Int J Pharm. 2015 Aug 1;491(1-2):198-207 - PubMed
  43. J Pharm Pharm Sci. 2009;12(3):288-311 - PubMed
  44. J Biomed Nanotechnol. 2015 Aug;11(8):1472-81 - PubMed
  45. J Drug Target. 2012 Feb;20(2):174-84 - PubMed
  46. Curr Pharm Des. 2015;21(36):5225-32 - PubMed
  47. Pharm Res. 2010 Apr;27(4):655-64 - PubMed
  48. Biomed Res Int. 2017;2017:5984014 - PubMed
  49. Biomaterials. 2013 May;34(15):3870-81 - PubMed
  50. J Control Release. 2011 Apr 30;151(2):131-8 - PubMed
  51. Med Devices (Auckl). 2015 Jan 06;8:57-64 - PubMed
  52. Mol Pharm. 2016 Nov 7;13(11):3773-3782 - PubMed
  53. Eur J Pharm Sci. 2000 Jul;11(1):1-18 - PubMed
  54. Eur J Pharm Sci. 2013 May 13;49(2):175-86 - PubMed
  55. Int J Pharm. 2013 Aug 16;452(1-2):300-10 - PubMed
  56. Biomaterials. 2013 Dec;34(36):9220-6 - PubMed
  57. Adv Drug Deliv Rev. 2009 Feb 27;61(2):158-71 - PubMed
  58. Int J Nanomedicine. 2016 Dec 07;11:6575-6590 - PubMed
  59. Curr Drug Deliv. 2016;13(4):557-64 - PubMed
  60. J Food Drug Anal. 2014 Mar;22(1):147-160 - PubMed
  61. Neurotherapeutics. 2009 Apr;6(2):359-71 - PubMed
  62. Antiviral Res. 2011 Dec;92(3):408-14 - PubMed
  63. Drug Deliv Transl Res. 2018 Feb;8(1):83-96 - PubMed
  64. Lancet Neurol. 2014 Jul;13(7):676-85 - PubMed
  65. Eur J Pharm Biopharm. 2009 May;72 (1):252-9 - PubMed
  66. Toxicol Lett. 2014 Aug 4;228(3):207-15 - PubMed
  67. J Pharm Pharmacol. 2004 Jan;56(1):3-17 - PubMed
  68. J Pharm Sci. 2010 Apr;99(4):1654-73 - PubMed
  69. Adv Drug Deliv Rev. 2004 Mar 3;56(4):425-35 - PubMed
  70. J Control Release. 2012 Feb 10;157(3):455-60 - PubMed
  71. Int J Nanomedicine. 2012;7:5705-18 - PubMed
  72. J Pharm Pharmacol. 2018 Jan;70(1):59-69 - PubMed
  73. Biomaterials. 2007 Aug;28(23):3448-55 - PubMed
  74. Bioconjug Chem. 2008 Nov 19;19(11):2189-95 - PubMed
  75. Drug Discov Today. 2018 Jan 9;:null - PubMed
  76. Part Fibre Toxicol. 2010 Dec 21;7:42 - PubMed
  77. Drug Dev Ind Pharm. 2017 Feb;43(2):234-245 - PubMed
  78. J Control Release. 2017 Oct 10;263:172-184 - PubMed
  79. Eur J Pharm Sci. 2011 Nov 20;44(4):559-65 - PubMed
  80. Pharmaceuticals (Basel). 2012 Oct 15;5(10):1092-102 - PubMed
  81. Acta Pharm. 2008 Sep;58(3):287-97 - PubMed
  82. Drug Deliv Transl Res. 2013 Feb;3(1):42-62 - PubMed
  83. J Drug Target. 2013 Sep;21(8):759-69 - PubMed
  84. Cell Mol Life Sci. 2005 Jun;62(12):1400-8 - PubMed
  85. J Comp Neurol. 1985 Dec 22;242(4):632-50 - PubMed
  86. Int J Nanomedicine. 2012;7:1373-85 - PubMed
  87. Int J Pharm. 2013 Aug 30;453(1):56-64 - PubMed
  88. Expert Opin Drug Deliv. 2015 Feb;12(2):181-94 - PubMed
  89. Int J Nanomedicine. 2015 Aug 04;10:4981-5003 - PubMed
  90. Ther Deliv. 2013 Mar;4(3):369-94 - PubMed
  91. Nanoscale. 2017 Jan 19;9(3):1174-1183 - PubMed
  92. Carbohydr Polym. 2012 Jun 5;89(1):72-9 - PubMed
  93. J Pharm Sci. 2014 Aug;103(8):2231-9 - PubMed
  94. Trends Cell Biol. 2011 Sep;21(9):543-51 - PubMed
  95. J Control Release. 2004 Aug 11;98 (2):231-44 - PubMed
  96. Eur J Pharm Sci. 2013 Sep 27;50(1):86-92 - PubMed
  97. Int J Pharm. 2010 Nov 15;400(1-2):183-93 - PubMed
  98. Angew Chem Int Ed Engl. 2008;47(50):9726-9 - PubMed
  99. Adv Drug Deliv Rev. 2012 May 15;64(7):686-700 - PubMed
  100. Pharm Res. 2013 Oct;30(10):2475-84 - PubMed
  101. Expert Opin Drug Deliv. 2015;12(9):1565-77 - PubMed
  102. Neurotoxicology. 2012 Aug;33(4):838-41 - PubMed
  103. Int J Pharm. 2008 Jun 24;358(1-2):285-91 - PubMed
  104. Int J Pharm. 2014 Oct 1;473(1-2):442-57 - PubMed
  105. Drug Deliv. 2016 Nov;23 (9):3681-3695 - PubMed
  106. Drug Discov Today. 2012 Apr;17(7-8):367-78 - PubMed
  107. Biomaterials. 2011 Sep;32(26):6285-90 - PubMed
  108. J Control Release. 2003 Feb 21;87(1-3):187-98 - PubMed
  109. AAPS J. 2015 May;17(3):493-505 - PubMed
  110. Drug Deliv Transl Res. 2012 Dec;2(6):498-507 - PubMed
  111. J Liposome Res. 2015;25(2):141-9 - PubMed
  112. J Control Release. 2007 Aug 28;121(3):156-67 - PubMed
  113. Dement Geriatr Cogn Disord. 2013;35(5-6):325-36 - PubMed
  114. Brain Res. 1995 Sep 18;692(1-2):278-82 - PubMed
  115. Drug Deliv. 2016 Nov;23 (9):3374-3386 - PubMed
  116. Drug Deliv. 2011 Nov;18(8):555-61 - PubMed
  117. Expert Opin Drug Deliv. 2015;12(12):1923-41 - PubMed
  118. Drug Dev Ind Pharm. 2016 Oct;42(10 ):1660-8 - PubMed
  119. J Control Release. 2014 Sep 28;190:189-200 - PubMed
  120. Front Neurosci. 2013 Mar 15;7:35 - PubMed
  121. Acta Pharm Sin B. 2016 Jul;6(4):352-8 - PubMed
  122. Mater Sci Eng C Mater Biol Appl. 2016 Jun;63:411-21 - PubMed
  123. Artif Cells Nanomed Biotechnol. 2016 May;44(3):865-77 - PubMed
  124. J Drug Target. 2014 May;22(4):279-94 - PubMed
  125. Colloids Surf B Biointerfaces. 2017 Apr 1;152:296-301 - PubMed
  126. Colloids Surf B Biointerfaces. 2012 Dec 1;100:146-54 - PubMed
  127. Biochim Biophys Acta. 2009 Apr;1788(4):892-910 - PubMed
  128. Neurobiol Dis. 2010 Jan;37(1):48-57 - PubMed
  129. Int J Nanomedicine. 2016 Dec 07;11:6547-6559 - PubMed
  130. AAPS PharmSciTech. 2015 Oct;16(5):1108-21 - PubMed
  131. Eur J Pharm Sci. 2007 Mar;30(3-4):295-302 - PubMed
  132. Drug Dev Ind Pharm. 2015;41(12):1922-34 - PubMed
  133. Toxicol Appl Pharmacol. 2011 Feb 15;251(1):79-84 - PubMed
  134. Artif Cells Nanomed Biotechnol. 2017 Dec 28;:1-8 - PubMed
  135. Pharm Res. 2011 Sep;28(9):2130-9 - PubMed
  136. Cancers (Basel). 2013 Aug 14;5(3):1020-48 - PubMed
  137. Bioorg Med Chem. 2017 Nov 4;:null - PubMed
  138. Eur J Pharm Biopharm. 2015 Aug;94:180-93 - PubMed
  139. Transl Psychiatry. 2017 May 23;7(5):e1136 - PubMed
  140. J Control Release. 2010 Feb 15;141(3):265-76 - PubMed
  141. Nanomedicine. 2014 May;10(4):755-64 - PubMed
  142. Drug Deliv. 2014 Mar;21(2):148-54 - PubMed
  143. Drug Deliv. 2016;23 (1):130-9 - PubMed
  144. J Drug Target. 2015;23(9):775-88 - PubMed
  145. Pharm Res. 2002 Aug;19(8):1185-93 - PubMed
  146. Colloids Surf B Biointerfaces. 2014 Oct 1;122:143-150 - PubMed
  147. Eur J Pharm Sci. 2013 Feb 14;48(3):393-405 - PubMed
  148. J Drug Target. 2007 Jan;15(1):59-66 - PubMed
  149. Nanomedicine (Lond). 2010 Jun;5(4):575-87 - PubMed
  150. Int J Pharm. 2012 May 30;428(1-2):164-70 - PubMed
  151. J Pharm Sci. 2012 Feb;101(2):690-706 - PubMed
  152. Biomaterials. 2006 Jun;27(18):3482-90 - PubMed
  153. Drug Deliv. 2016 Sep;23 (7):2095-2114 - PubMed
  154. J Control Release. 2018 Jan 28;270:89-100 - PubMed
  155. Neurology. 2008 Feb 5;70(6):440-8 - PubMed
  156. Adv Drug Deliv Rev. 2009 Sep 30;61(11):953-64 - PubMed
  157. J Drug Target. 2009 Aug;17(7):543-52 - PubMed
  158. J Drug Deliv. 2013;2013:374252 - PubMed
  159. Drug Dev Ind Pharm. 2015;41(10):1674-81 - PubMed
  160. Ther Deliv. 2012 Feb;3(2):195-208 - PubMed
  161. J Drug Target. 2006 Jun;14(5):281-90 - PubMed
  162. Eur J Pharm Sci. 2010 Aug 11;40(5):385-403 - PubMed
  163. Curr Top Med Chem. 2014;14(9):1182-93 - PubMed
  164. Int J Pharm. 2016 Feb 29;499(1-2):81-89 - PubMed
  165. Neuroscience. 2004;127(2):481-96 - PubMed
  166. Eur J Pharm Sci. 2012 Aug 30;47(1):6-15 - PubMed
  167. J Control Release. 2013 Sep 10;170(2):279-86 - PubMed
  168. Int J Nanomedicine. 2017 Nov 28;12 :8531-8543 - PubMed
  169. J Alzheimers Dis. 2017;57(4):1325-1334 - PubMed
  170. J Control Release. 2013 Oct 10;171(1):17-23 - PubMed

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