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Vogelgesang S, Niebert M, Bischoff AM, et al. Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice. Front Mol Neurosci. 2018;11:28doi: 10.3389/fnmol.2018.00028.
Vogelgesang, S., Niebert, M., Bischoff, A. M., Hülsmann, S., & Manzke, T. (2018). Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice. Frontiers in molecular neuroscience, 1128. https://doi.org/10.3389/fnmol.2018.00028
Vogelgesang, Steffen, et al. "Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice." Frontiers in molecular neuroscience vol. 11 (2018): 28. doi: https://doi.org/10.3389/fnmol.2018.00028
Vogelgesang S, Niebert M, Bischoff AM, Hülsmann S, Manzke T. Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice. Front Mol Neurosci. 2018 Feb 20;11:28. doi: 10.3389/fnmol.2018.00028. eCollection 2018. PMID: 29515365; PMCID: PMC5826236.
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Front Mol Neurosci. 2018 Feb 20;11:28. doi: 10.3389/fnmol.2018.00028. eCollection 2018.

Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice.

Frontiers in molecular neuroscience

Steffen Vogelgesang, Marcus Niebert, Anne M Bischoff, Swen Hülsmann, Till Manzke

Affiliations

  1. DFG-Research Center Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), University of Göttingen, Göttingen, Germany.
  2. Institute of Neuro- and Sensory Physiology, University of Göttingen, Göttingen, Germany.
  3. Clinic for Anesthesiology, University Medical Göttingen, Göttingen, Germany.

PMID: 29515365 PMCID: PMC5826236 DOI: 10.3389/fnmol.2018.00028

Abstract

Mutations in the transcription factor methyl-CpG-binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome (RTT). Besides many other neurological problems, RTT patients show irregular breathing with recurrent apneas or breath-holdings. MeCP2-deficient mice, which recapitulate this breathing phenotype, show a dysregulated, persistent expression of G-protein-coupled serotonin receptor 5-ht

Keywords: 5-ht5b receptor; GPCR; MeCP2; Rett syndrome; breathing disturbances; cAMP regulation

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