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Meshram GG, Kaur N, Hura KS. Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies. Case Rep Dermatol. 2018;10(1):24-28doi: 10.1159/000487002.
Meshram, G. G., Kaur, N., & Hura, K. S. (2018). Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies. Case reports in dermatology, 10(1), 24-28. https://doi.org/10.1159/000487002
Meshram, Girish Gulab, et al. "Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies." Case reports in dermatology vol. 10,1 (2018): 24-28. doi: https://doi.org/10.1159/000487002
Meshram GG, Kaur N, Hura KS. Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies. Case Rep Dermatol. 2018 Feb 08;10(1):24-28. doi: 10.1159/000487002. eCollection 2018. PMID: 29515391; PMCID: PMC5836163.
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Case Rep Dermatol. 2018 Feb 08;10(1):24-28. doi: 10.1159/000487002. eCollection 2018.

Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies.

Case reports in dermatology

Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura

Affiliations

  1. aDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
  2. bDepartment of Radiology, The University of Texas Health Science Center, San Antonio, TX, USA.
  3. cDepartment of Pediatrics, Richmond University Medical Center, New York, NY, USA.

PMID: 29515391 PMCID: PMC5836163 DOI: 10.1159/000487002

Abstract

Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature.

Keywords: Giant congenital melanocytic nevi; Malignant melanoma; Neurocutaneous melanosis

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