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Ota S, Haruyama T, Ishihara M, et al. A Patient with Advanced Gastric Cancer Who Achieved a Long-Term Prognosis by Early Diagnosis of Sister Mary Joseph's Nodule. Case Rep Oncol. 2018;11(1):11-16doi: 10.1159/000484976.
Ota, S., Haruyama, T., Ishihara, M., Natsume, M., Fukasawa, Y., Sakamoto, T., Tanzawa, S., Usui, R., Honda, T., Ichikawa, Y., Watanabe, K., Sasajima, Y., & Seki, N. (2018). A Patient with Advanced Gastric Cancer Who Achieved a Long-Term Prognosis by Early Diagnosis of Sister Mary Joseph's Nodule. Case reports in oncology, 11(1), 11-16. https://doi.org/10.1159/000484976
Ota, Shuji, et al. "A Patient with Advanced Gastric Cancer Who Achieved a Long-Term Prognosis by Early Diagnosis of Sister Mary Joseph's Nodule." Case reports in oncology vol. 11,1 (2018): 11-16. doi: https://doi.org/10.1159/000484976
Ota S, Haruyama T, Ishihara M, Natsume M, Fukasawa Y, Sakamoto T, Tanzawa S, Usui R, Honda T, Ichikawa Y, Watanabe K, Sasajima Y, Seki N. A Patient with Advanced Gastric Cancer Who Achieved a Long-Term Prognosis by Early Diagnosis of Sister Mary Joseph's Nodule. Case Rep Oncol. 2018 Jan 04;11(1):11-16. doi: 10.1159/000484976. eCollection 2018. PMID: 29515403; PMCID: PMC5836228.
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Case Rep Oncol. 2018 Jan 04;11(1):11-16. doi: 10.1159/000484976. eCollection 2018.

A Patient with Advanced Gastric Cancer Who Achieved a Long-Term Prognosis by Early Diagnosis of Sister Mary Joseph's Nodule.

Case reports in oncology

Shuji Ota, Terunobu Haruyama, Masashi Ishihara, Maika Natsume, Yoko Fukasawa, Takahiko Sakamoto, Shigeru Tanzawa, Ryo Usui, Takeshi Honda, Yasuko Ichikawa, Kiyotaka Watanabe, Yuko Sasajima, Nobuhiko Seki

Affiliations

  1. aDivision of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
  2. bDivision of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

PMID: 29515403 PMCID: PMC5836228 DOI: 10.1159/000484976

Abstract

The patient was a 66-year-old woman. An induration of approximately 15 mm in size that accompanied redness was palpable in the umbilical fossa. She did not respond to 1-month antibiotic treatment provided by the previous physician. For this reason, a biopsy of the site was performed with the possibility of neoplastic disease in mind, resulting in the detection of adenocarcinoma. Subsequent detailed whole-body examination revealed advanced gastric cancer and peritoneal dissemination, and the induration in the umbilical fossa was diagnosed as a direct infiltration from the peritoneal dissemination. Metastasis or infiltration of malignant tumor to the umbilicus is called Sister Mary Joseph's nodule (SMJN), and considered as a sign of poor prognosis. However, this case was successfully treated and achieved a long-term prognosis by the early diagnosis of SMJN. In routine clinical practice, it is considered necessary to examine patients carefully, as not to overlook SMJN.

Keywords: Chemotherapy; Gastric cancer; Sister Mary Joseph's nodule

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