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Yoshida T, Tsujimoto H, Ichikawa T, et al. Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome. Case Rep Oncol. 2018;11(1):63-67doi: 10.1159/000486364.
Yoshida, T., Tsujimoto, H., Ichikawa, T., Kounami, S., & Suzuki, H. (2018). Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome. Case reports in oncology, 11(1), 63-67. https://doi.org/10.1159/000486364
Yoshida, Tatsunori, et al. "Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome." Case reports in oncology vol. 11,1 (2018): 63-67. doi: https://doi.org/10.1159/000486364
Yoshida T, Tsujimoto H, Ichikawa T, Kounami S, Suzuki H. Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome. Case Rep Oncol. 2018 Feb 01;11(1):63-67. doi: 10.1159/000486364. eCollection 2018. PMID: 29515412; PMCID: PMC5836153.
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Case Rep Oncol. 2018 Feb 01;11(1):63-67. doi: 10.1159/000486364. eCollection 2018.

Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome.

Case reports in oncology

Tatsunori Yoshida, Hiroshi Tsujimoto, Takayuki Ichikawa, Shinji Kounami, Hiroyuki Suzuki

Affiliations

  1. Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan.

PMID: 29515412 PMCID: PMC5836153 DOI: 10.1159/000486364

Abstract

Acute lymphoblastic leukemia (ALL) presenting as Fanconi syndrome (FS) is extremely rare. Here, we report a case of ALL presenting as bilateral nephromegaly following FS. A 2-year-old girl was unexpectedly diagnosed with bilateral nephromegaly. After 2 weeks, she developed general fatigue, thirst, and polyuria. Laboratory examinations revealed renal tubular acidosis, hypokalemia, hypophosphatemia, and aminoaciduria, and FS was diagnosed. Replacement of bicarbonate and potassium did not improve her condition. Two weeks after the onset of FS, leukemic cells appeared on a peripheral blood smear, and the patient was diagnosed with precursor B-cell ALL presenting as nephromegaly and FS. Chemotherapy brought about a prompt resolution of acidosis and electrolyte abnormalities, without renal dysfunction. The patient remains well 4 years after the onset of the disease. Although extremely rare, FS should be recognized as one of the emerging renal complications of ALL.

Keywords: Acute lymphoblastic leukemia; Fanconi syndrome; Nephromegaly; Renal tubular acidosis

References

  1. QJM. 2014 Apr;107(4):261-9 - PubMed
  2. Croat Med J. 2007 Dec;48(6):860-3 - PubMed
  3. Indian J Hematol Blood Transfus. 2011 Mar;27(1):43-5 - PubMed
  4. J Am Soc Nephrol. 2016 May;27(5):1555-65 - PubMed
  5. Pediatr Nephrol. 2005 May;20(5):679-82 - PubMed
  6. Adv Chronic Kidney Dis. 2014 Jan;21(1):27-35 - PubMed
  7. Orv Hetil. 1985 Mar 3;126(9):531-3 - PubMed
  8. Am J Hematol. 1999 Dec;62(4):201-7 - PubMed
  9. J Postgrad Med. 2017 Oct-Dec;63(4):271-272 - PubMed
  10. Indian J Hematol Blood Transfus. 2016 Jun;32(Suppl 1):5-7 - PubMed
  11. Med Princ Pract. 2008;17(6):504-6 - PubMed
  12. Clin Nephrol. 1982 Jun;17(6):319-22 - PubMed
  13. Pediatr Med Chir. 1982 Jan-Apr;4(1-2):107-13 - PubMed
  14. J Pediatr Hematol Oncol. 2003 Jun;25(6):488-90 - PubMed
  15. Nephrol Dial Transplant. 2010 Aug;25(8):2516-20 - PubMed

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