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Slater PG, Gutierrez-Maldonado SE, Gysling K, et al. Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor. Front Endocrinol (Lausanne). 2018;9:43doi: 10.3389/fendo.2018.00043.
Slater, P. G., Gutierrez-Maldonado, S. E., Gysling, K., & Lagos, C. F. (2018). Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor. Frontiers in endocrinology, 943. https://doi.org/10.3389/fendo.2018.00043
Slater, Paula G, et al. "Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor." Frontiers in endocrinology vol. 9 (2018): 43. doi: https://doi.org/10.3389/fendo.2018.00043
Slater PG, Gutierrez-Maldonado SE, Gysling K, Lagos CF. Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor. Front Endocrinol (Lausanne). 2018 Feb 20;9:43. doi: 10.3389/fendo.2018.00043. eCollection 2018. PMID: 29515519; PMCID: PMC5826306.
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Front Endocrinol (Lausanne). 2018 Feb 20;9:43. doi: 10.3389/fendo.2018.00043. eCollection 2018.

Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor.

Frontiers in endocrinology

Paula G Slater, Sebastian E Gutierrez-Maldonado, Katia Gysling, Carlos F Lagos

Affiliations

  1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
  2. Computational Biology Laboratory (DLab), Fundación Ciencia & Vida, Santiago, Chile.
  3. Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

PMID: 29515519 PMCID: PMC5826306 DOI: 10.3389/fendo.2018.00043

Abstract

The corticotropin-releasing factor (CRF) system is a key mediator of the stress response and addictive behavior. The CRF system includes four peptides: The CRF system includes four peptides: CRF, urocortins I-III, CRF binding protein (CRF-BP) that binds CRF with high affinity, and two class B G-protein coupled receptors CRF

Keywords: class B G-protein coupled receptor; corticotropin-releasing factor; corticotropin-releasing factor binding protein; corticotropin-releasing factor receptor; molecular dynamics; molecular modeling; protein-protein docking

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