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Camargos P, Affonso A, Calazans G, et al. On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clin Transl Allergy. 2018;8:7doi: 10.1186/s13601-018-0192-0.
Camargos, P., Affonso, A., Calazans, G., Ramalho, L., Ribeiro, M. L., Jentzsch, N., Senna, S., & Stein, R. T. (2018). On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clinical and translational allergy, 87. https://doi.org/10.1186/s13601-018-0192-0
Camargos, Paulo, et al. "On-demand intermittent beclomethasone is effective for mild asthma in Brazil." Clinical and translational allergy vol. 8 (2018): 7. doi: https://doi.org/10.1186/s13601-018-0192-0
Camargos P, Affonso A, Calazans G, Ramalho L, Ribeiro ML, Jentzsch N, Senna S, Stein RT. On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clin Transl Allergy. 2018 Mar 05;8:7. doi: 10.1186/s13601-018-0192-0. eCollection 2018. PMID: 29515802; PMCID: PMC5836456.
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Clin Transl Allergy. 2018 Mar 05;8:7. doi: 10.1186/s13601-018-0192-0. eCollection 2018.

On-demand intermittent beclomethasone is effective for mild asthma in Brazil.

Clinical and translational allergy

Paulo Camargos, Alessandra Affonso, Geralda Calazans, Lidiana Ramalho, Marisa L Ribeiro, Nulma Jentzsch, Simone Senna, Renato T Stein

Affiliations

  1. 1Pediatric Pulmonology Unit, University Hospital, Federal University of Minas Gerais, Avenida Alfredo Balena 190, Room 267, Belo Horizonte, 30130-100 Brazil.
  2. Municipal Public Health Department, Belo Horizonte, Brazil.
  3. 3Laboratory of Pediatric Respirology, Infant Center, Institute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

PMID: 29515802 PMCID: PMC5836456 DOI: 10.1186/s13601-018-0192-0

Abstract

BACKGROUND: Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persistent asthma.

METHODS: In this 16-week trial, children aged 6-18 years were evaluated. Subjects in the continuous treatment arm of the study received 500 μg/day of beclomethasone, whereas the intermittent ones were given 1000 μg/day (250 μg every 6 h) in combination with albuterol for 7 days upon exacerbations or worsening of symptoms. Primary outcome (i.e., treatment failure) was the occurrence of any asthma exacerbation requiring prednisone, and co-secondary outcomes were the mean/median differences for both, (1) the pre-bronchodilator FEV

RESULTS: Ninety-four subjects from each treatment arm were included. They were comparable regarding all baseline characteristics; prednisone was used by 10 (10.6%) and 7 (7.4%) patients, respectively (95% CI - 6.1 to 12.6%, for the difference; p = 0.47). Statistical analysis showed no statistically significant differences with respect to both FEV

CONCLUSION: Clinicians might consider intermittent inhaled steroid therapy as a therapeutic regimen for mild persistent asthma.

Keywords: Asthma management; Asthma treatment; Pediatric asthma

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