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Miyazawa T, Kamiyoshihara R, Shimizu N, et al. Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes. R Soc Open Sci. 2018;5(2):171249doi: 10.1098/rsos.171249.
Miyazawa, T., Kamiyoshihara, R., Shimizu, N., Harigae, T., Otoki, Y., Ito, J., Kato, S., Miyazawa, T., & Nakagawa, K. (2018). Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes. Royal Society open science, 5(2), 171249. https://doi.org/10.1098/rsos.171249
Miyazawa, Taiki, et al. "Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes." Royal Society open science vol. 5,2 (2018): 171249. doi: https://doi.org/10.1098/rsos.171249
Miyazawa T, Kamiyoshihara R, Shimizu N, Harigae T, Otoki Y, Ito J, Kato S, Miyazawa T, Nakagawa K. Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes. R Soc Open Sci. 2018 Feb 14;5(2):171249. doi: 10.1098/rsos.171249. eCollection 2018 Feb. PMID: 29515844; PMCID: PMC5830733.
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R Soc Open Sci. 2018 Feb 14;5(2):171249. doi: 10.1098/rsos.171249. eCollection 2018 Feb.

Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes.

Royal Society open science

Taiki Miyazawa, Reina Kamiyoshihara, Naoki Shimizu, Takahiro Harigae, Yurika Otoki, Junya Ito, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa

Affiliations

  1. Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-0845, Japan.
  2. Department of Cell Biology, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
  3. Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan.
  4. Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai 980-0845, Japan.

PMID: 29515844 PMCID: PMC5830733 DOI: 10.1098/rsos.171249

Abstract

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

Keywords: Amadori-glycated phosphatidylethanolamine; Maillard reaction product; curcumin; glucose transporter; glycolipid; liposome

Conflict of interest statement

We declare we have no competing interests.

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