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Demjén A, Angyal A, Wölfling J, et al. One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines. Org Biomol Chem. 2018;16(12):2143-2149doi: 10.1039/c7ob03109b.
Demjén, A., Angyal, A., Wölfling, J., Puskás, L. G., & Kanizsai, I. (2018). One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines. Organic & biomolecular chemistry, 16(12), 2143-2149. https://doi.org/10.1039/c7ob03109b
Demjén, András, et al. "One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines." Organic & biomolecular chemistry vol. 16,12 (2018): 2143-2149. doi: https://doi.org/10.1039/c7ob03109b
Demjén A, Angyal A, Wölfling J, Puskás LG, Kanizsai I. One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines. Org Biomol Chem. 2018 Mar 28;16(12):2143-2149. doi: 10.1039/c7ob03109b. Epub 2018 Mar 08. PMID: 29517090.
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Org Biomol Chem. 2018 Mar 28;16(12):2143-2149. doi: 10.1039/c7ob03109b. Epub 2018 Mar 08.

One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines.

Organic & biomolecular chemistry

András Demjén, Anikó Angyal, János Wölfling, László G Puskás, Iván Kanizsai

Affiliations

  1. AVIDIN Ltd, Alsó kiköt? sor 11/D, Szeged, H-6726, Hungary. [email protected] and Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary.
  2. Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary.
  3. AVIDIN Ltd, Alsó kiköt? sor 11/D, Szeged, H-6726, Hungary. [email protected].

PMID: 29517090 DOI: 10.1039/c7ob03109b

Abstract

A sequential one-pot approach towards N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.

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