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Al-Nemrawi NK, Alshraiedeh NH, Zayed AL, et al. Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis. Pharmaceuticals (Basel). 2018;11(1)doi: 10.3390/ph11010028.
Al-Nemrawi, N. K., Alshraiedeh, N. H., Zayed, A. L., & Altaani, B. M. (2018). Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis. Pharmaceuticals (Basel, Switzerland), 11(1), . https://doi.org/10.3390/ph11010028
Al-Nemrawi, Nusaiba K, et al. "Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis." Pharmaceuticals (Basel, Switzerland) vol. 11,1 (2018). doi: https://doi.org/10.3390/ph11010028
Al-Nemrawi NK, Alshraiedeh NH, Zayed AL, Altaani BM. Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis. Pharmaceuticals (Basel). 2018 Mar 08;11(1). doi: 10.3390/ph11010028. PMID: 29517998; PMCID: PMC5874724.
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Pharmaceuticals (Basel). 2018 Mar 08;11(1). doi: 10.3390/ph11010028.

Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis.

Pharmaceuticals (Basel, Switzerland)

Nusaiba K Al-Nemrawi, Nid''A H Alshraiedeh, Aref L Zayed, Bashar M Altaani

Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. [email protected].
  2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. [email protected].
  3. Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. [email protected].
  4. Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. [email protected].

PMID: 29517998 PMCID: PMC5874724 DOI: 10.3390/ph11010028

Abstract

(1) Background: Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with Tobramycin were prepared using a solvent-evaporation method. (2) Methods: The NPs were coated with low molecular weight chitosan (LMWC) to enhance the mucoadhesiveness of PLGA-NPs. The following

Keywords: PLGA; chitosan; cystic fibrosis; mucoadhesive nanoparticle; tobramycin

Conflict of interest statement

The authors declare no conflict of interest.

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