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Tian F, Liu T, Xu G, et al. Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest. Front Physiol. 2018;9:99doi: 10.3389/fphys.2018.00099.
Tian, F., Liu, T., Xu, G., Li, D., Ghazi, T., Shick, T., Sajjad, A., Wang, M. M., Farrehi, P., & Borjigin, J. (2018). Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest. Frontiers in physiology, 999. https://doi.org/10.3389/fphys.2018.00099
Tian, Fangyun, et al. "Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest." Frontiers in physiology vol. 9 (2018): 99. doi: https://doi.org/10.3389/fphys.2018.00099
Tian F, Liu T, Xu G, Li D, Ghazi T, Shick T, Sajjad A, Wang MM, Farrehi P, Borjigin J. Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest. Front Physiol. 2018 Feb 13;9:99. doi: 10.3389/fphys.2018.00099. eCollection 2018. PMID: 29487541; PMCID: PMC5816970.
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Front Physiol. 2018 Feb 13;9:99. doi: 10.3389/fphys.2018.00099. eCollection 2018.

Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest.

Frontiers in physiology

Fangyun Tian, Tiecheng Liu, Gang Xu, Duan Li, Talha Ghazi, Trevor Shick, Azeem Sajjad, Michael M Wang, Peter Farrehi, Jimo Borjigin

Affiliations

  1. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
  2. Department of Neurology, University of Michigan, Ann Arbor, MI, United States.
  3. Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, United States.
  4. Cardiovascular Center, University of Michigan, Ann Arbor, MI, United States.
  5. Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI, United States.
  6. Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, United States.
  7. Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI, United States.

PMID: 29487541 PMCID: PMC5816970 DOI: 10.3389/fphys.2018.00099

Abstract

Sudden cardiac arrest is a leading cause of death in the United States. The neurophysiological mechanism underlying sudden death is not well understood. Previously we have shown that the brain is highly stimulated in dying animals and that asphyxia-induced death could be delayed by blocking the intact brain-heart neuronal connection. These studies suggest that the autonomic nervous system plays an important role in mediating sudden cardiac arrest. In this study, we tested the effectiveness of phentolamine and atenolol, individually or combined, in prolonging functionality of the vital organs in CO

Keywords: asphyxic cardiac arrest; atenolol; autonomic nervous system; coherence; directional connectivity; phentolamine

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