Display options
Cite
Greuter T, Franc Y, Kaelin M, et al. Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients. Therap Adv Gastroenterol. 2018;11:1756283X18757715doi: 10.1177/1756283X18757715.
Greuter, T., Franc, Y., Kaelin, M., Schoepfer, A. M., Schreiner, P., Zeitz, J., Scharl, M., Misselwitz, B., Straumann, A., Vavricka, S. R., Rogler, G., von Känel, R., & Biedermann, L. (2018). Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients. Therapeutic advances in gastroenterology, 111756283X18757715. https://doi.org/10.1177/1756283X18757715
Greuter, Thomas, et al. "Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients." Therapeutic advances in gastroenterology vol. 11 (2018): 1756283X18757715. doi: https://doi.org/10.1177/1756283X18757715
Greuter T, Franc Y, Kaelin M, Schoepfer AM, Schreiner P, Zeitz J, Scharl M, Misselwitz B, Straumann A, Vavricka SR, Rogler G, von Känel R, Biedermann L. Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients. Therap Adv Gastroenterol. 2018 Feb 19;11:1756283X18757715. doi: 10.1177/1756283X18757715. eCollection 2018. PMID: 29487628; PMCID: PMC5821298.
Copy Download .nbib Format: NLM
Share it on

Therap Adv Gastroenterol. 2018 Feb 19;11:1756283X18757715. doi: 10.1177/1756283X18757715. eCollection 2018.

Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.

Therapeutic advances in gastroenterology

Thomas Greuter, Yannick Franc, Matthias Kaelin, Alain M Schoepfer, Philipp Schreiner, Jonas Zeitz, Michael Scharl, Benjamin Misselwitz, Alex Straumann, Stephan R Vavricka, Gerhard Rogler, Roland von Känel, Luc Biedermann

Affiliations

  1. Department of Gastroenterology and Hepatology, University Hospital Zurich, Switzerland.
  2. Institute of Social and Preventive Medicine, University of Lausanne, Switzerland.
  3. Unilabs Switzerland, Dübendorf, Switzerland.
  4. Division of Gastroenterology and Hepatology, University Hospital Lausanne - CHUV, Switzerland.
  5. Praxis Römerhof, Olten, Switzerland.
  6. Department of Psychosomatic Medicine, Clinic Barmelweid, Switzerland.
  7. Department of Gastroenterology and Hepatology, University Hospital Zurich, Raemistrasse 100, 8006 Zurich.

PMID: 29487628 PMCID: PMC5821298 DOI: 10.1177/1756283X18757715

Abstract

BACKGROUND: Zinc deficiency (ZD) in Crohn's disease (CD) is considered a frequent finding and may exacerbate CD activity. ZD is associated with depression in non-CD patients. We aimed to assess the prevalence of ZD in CD patients in clinical remission, its association with mood disturbances and to analyze a potential impact on future disease course.

METHODS: Zinc levels from CD patients in clinical remission at baseline and an uncomplicated disease course within the next 3 years (

RESULTS: Mean zinc level in the 97 patients (40.4 ± 15.7 years, 44.3% males) was 18.0 ± 4.7 μmol/l. While no ZD (<11 μmol/l) was observed, we found low zinc levels (<15.1 μmol/l) in 28 patients (28.9%). Males had higher zinc levels compared with females (19.4 ± 5.7

CONCLUSION: Low-normal zinc levels were an independent predictor for the presence of depression symptoms in CD patients. Zinc levels at baseline did not predict a complicated disease course, neither in CD patients overall, nor ATG16L1

Keywords: ATG16L1; Crohn’s disease; anxiety; depression; disease course; single nucleotide polymorphism; zinc

Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

References

  1. Biol Psychiatry. 2013 Dec 15;74(12):872-8 - PubMed
  2. J Lab Clin Med. 2002 May;139(5):311-5 - PubMed
  3. J Trace Elem Med Biol. 1997 Jun;11(2):92-8 - PubMed
  4. J Affect Disord. 2009 Nov;118(1-3):187-95 - PubMed
  5. Inflamm Bowel Dis. 2001 May;7(2):94-8 - PubMed
  6. Gut. 2012 Aug;61(8):1140-5 - PubMed
  7. Gastroenterology. 2006 Jun;130(7):2201-5 - PubMed
  8. Cell Mol Life Sci. 2002 Apr;59(4):627-47 - PubMed
  9. Mediators Inflamm. 2009;2009:729172 - PubMed
  10. Lancet. 2016 Jan 9;387(10014):156-67 - PubMed
  11. Am J Clin Nutr. 2003 Oct;78(4):756-64 - PubMed
  12. Inflamm Bowel Dis. 2016 Mar;22(3):752-62 - PubMed
  13. Int J Epidemiol. 2015 Dec;44(6):1995-2005 - PubMed
  14. Am J Gastroenterol. 2011 Apr;106(4):563-73 - PubMed
  15. PLoS One. 2015 Jan 30;10(1):e0117257 - PubMed
  16. Pharmacol Rep. 2012;64(2):249-55 - PubMed
  17. Nat Rev Gastroenterol Hepatol. 2015 Apr;12(4):205-17 - PubMed
  18. J Trace Elem Med Biol. 2002;16(2):75-81 - PubMed
  19. Acta Psychiatr Scand. 1983 Jun;67(6):361-70 - PubMed
  20. Indian J Pediatr. 2015 May;82(5):415-20 - PubMed
  21. Biol Trace Elem Res. 2010 Nov;137(2):150-8 - PubMed
  22. Nat Genet. 2007 May;39(5):596-604 - PubMed
  23. Am J Psychiatry. 2016 Jun 1;173(6):575-87 - PubMed
  24. Inflamm Bowel Dis. 2006 Mar;12(3):185-91 - PubMed
  25. J Immunol. 1996 Feb 1;156(3):1166-73 - PubMed
  26. Exp Gerontol. 2008 May;43(5):370-7 - PubMed
  27. Clin Gastroenterol Hepatol. 2016 Jun;14 (6):829-835.e1 - PubMed
  28. Biol Trace Elem Res. 2017 Aug;178(2):180-188 - PubMed
  29. Toxicology. 2005 Dec 15;216(2-3):188-96 - PubMed
  30. Lancet Psychiatry. 2015 Mar;2(3):271-4 - PubMed
  31. Pol J Pharmacol. 2003 Nov-Dec;55(6):1143-7 - PubMed
  32. J Nutr. 2008 Sep;138(9):1664-70 - PubMed
  33. World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):496-513 - PubMed
  34. Biol Psychiatry. 1997 Sep 1;42(5):349-58 - PubMed
  35. J Nutr Sci. 2015 Apr 20;4:e15 - PubMed
  36. Physiol Behav. 2008 Oct 20;95(3):365-9 - PubMed
  37. Int J Epidemiol. 2009 Aug;38(4):922-31 - PubMed
  38. J Affect Disord. 2010 Nov;126(3):447-52 - PubMed
  39. PLoS One. 2013 Dec 19;8(12):e82793 - PubMed
  40. J Crohns Colitis. 2017 Jan;11(1):3-25 - PubMed
  41. Inflamm Bowel Dis. 2010 Jan;16(1):137-51 - PubMed
  42. Eur J Gastroenterol Hepatol. 2013 Apr;25(4):393-8 - PubMed
  43. Exp Neurol. 2001 Jul;170(1):1-14 - PubMed
  44. Pharmacol Rep. 2014 Aug;66(4):534-44 - PubMed
  45. Nutrients. 2013 Nov 21;5(11):4715-40 - PubMed
  46. Dig Dis. 2016;34(1-2):58-63 - PubMed
  47. Biometals. 2014 Dec;27(6):1087-96 - PubMed
  48. Digestion. 1983;27(2):70-4 - PubMed
  49. Lancet. 1993 Jun 5;341(8858):1437-9 - PubMed
  50. JPEN J Parenter Enteral Nutr. 2007 Jul-Aug;31(4):311-9 - PubMed
  51. Clin Transl Gastroenterol. 2015 Nov 05;6:e122 - PubMed
  52. Scand J Gastroenterol. 1998 Jun;33(6):644-9 - PubMed
  53. Biogerontology. 2006 Oct-Dec;7(5-6):339-45 - PubMed

Publication Types