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Ross Agner BF, Katz MG, Williams ZR, et al. Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm. J Atr Fibrillation. 2017;10(4):1437doi: 10.4022/jafib.1437.
Ross Agner, B. F., Katz, M. G., Williams, Z. R., Dixen, U., Jensen, G. B., & Schwarz, K. Q. (2017). Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm. Journal of atrial fibrillation, 10(4), 1437. https://doi.org/10.4022/jafib.1437
Ross Agner, Bue F, et al. "Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm." Journal of atrial fibrillation vol. 10,4 (2017): 1437. doi: https://doi.org/10.4022/jafib.1437
Ross Agner BF, Katz MG, Williams ZR, Dixen U, Jensen GB, Schwarz KQ. Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm. J Atr Fibrillation. 2017 Dec 31;10(4):1437. doi: 10.4022/jafib.1437. eCollection 2017 Dec. PMID: 29487674; PMCID: PMC5821625.
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J Atr Fibrillation. 2017 Dec 31;10(4):1437. doi: 10.4022/jafib.1437. eCollection 2017 Dec.

Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm.

Journal of atrial fibrillation

Bue F Ross Agner, Michael G Katz, Zachary R Williams, Ulrik Dixen, Gorm B Jensen, Karl Q Schwarz

Affiliations

  1. Hvidovre University Hospital, Department of Cardiology, Copenhagen, Denmark.
  2. University of Rochester Medical Center, Department of Cardiology, Rochester, New York, USA.

PMID: 29487674 PMCID: PMC5821625 DOI: 10.4022/jafib.1437

Abstract

BACKGROUND: Atrial fibrillation (AF) is the most common aberrant cardiac arrhythmia. Many AF patients present with symptoms of dyspnea and fatigue, but have normal left ventricular ejection fraction (LVEF).

PURPOSE: To determine the reproducibility of measurements of global longitudinal strain (GLS) and strain rate in patients with AF and examine if the arrhythmia is associated with abnormal LV strain and strain rate independent of age, sex, heart rate, LVEF and LV mass. We hypothesized that AF independently reduces ventricular systolic performance.

METHODS: The study was conducted as a retrospective analysis of images from 150 randomly selected patients with AF compared to an equal number of subjects with sinus rhythm (SR) matched for age, sex, heart rate, LVEF and LV mass. Half of the patients had normal LVEF (LVEF > 50%) and half had reduced LVEF (LVEF < 50%). GLS and strain rate were measured in each group, as were quantitative LV volumes and standard systolic and diastolic parameters. Results: GLS was significantly impaired in patients with AF compared to subjects with SR, both in the overall population (-12.25 ± 4.1% vs. -16.13 ± 4.7%, p<0.0001), in patients with normal LVEF (-14.41 ± 3.9% vs. -19.42 ± 3.1%, p<0.0001) and in patients with reduced LVEF (-10.10 ± 3.1% vs. -12.85 ± 3.5%, p<0.0001).Linear regression and Bland Altman analyses demonstrated good intraobserver and interobserver agreement for measurements of GLS and strain rate parameters even in patients with AF.

Keywords: Atrial Fibrillation; Diastolic strain rate.; Global longitudinal strain; Left ventricular systolic function; Systolic strain; Systolic strain rate

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