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Hu ZC, Tan YL, Huang SG, et al. Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception. Oncotarget. 2017;9(8):7882-7890doi: 10.18632/oncotarget.23609.
Hu, Z. C., Tan, Y. L., Huang, S. G., Pan, P., Liu, X. B., Wang, J., & Guo, W. L. (2018). Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception. Oncotarget, 9(8), 7882-7890. https://doi.org/10.18632/oncotarget.23609
Hu, Zhang-Chun, et al. "Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception." Oncotarget vol. 9,8 (2018): 7882-7890. doi: https://doi.org/10.18632/oncotarget.23609
Hu ZC, Tan YL, Huang SG, Pan P, Liu XB, Wang J, Guo WL. Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception. Oncotarget. 2017 Dec 22;9(8):7882-7890. doi: 10.18632/oncotarget.23609. eCollection 2018 Jan 30. PMID: 29487699; PMCID: PMC5814266.
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Oncotarget. 2017 Dec 22;9(8):7882-7890. doi: 10.18632/oncotarget.23609. eCollection 2018 Jan 30.

Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception.

Oncotarget

Zhang-Chun Hu, Ya-Lan Tan, Shun-Gen Huang, Peng Pan, Xiao-Bo Liu, Jian Wang, Wan-Liang Guo

Affiliations

  1. Radiology Department, Children's Hospital of Soochow University, Suzhou, 215003, China.
  2. General Surgery Department, Children's Hospital of Soochow University, Suzhou, 215003, China.

PMID: 29487699 PMCID: PMC5814266 DOI: 10.18632/oncotarget.23609

Abstract

We investigated the expression of Toll-like receptor 4 (TLR4) in the acute phase of intestinal I/R injury during intussusception and evaluated whether anti-TLR4 antibody-conjugated lead sulfide quantum dots (TLR4-PbS QDs) could be used to detect and monitor the injury. We first established a mouse model of I/R injury during intussusception. TLR-PbS QDs were then intravenously administered to intestinal I/R injured mice and visualized using whole-body fluorescence imaging in the second near-infrared window (NIR-II). Immunohistochemical analysis of intestinal tissue from the mice revealed that TLR4 expression was higher in the I/R injury group than the control and TAK-242 groups (5.189 ± 2.482, 1.186 ± 1.171, and 2.400 ± 0.857, respectively,

Keywords: PbS quantum dots; TLR4; in vivo imaging; intussusception; ischemia-reperfusion

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there are no conflicts of interest.

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