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Toxicol Rep. 2018 Feb 03;5:270-277. doi: 10.1016/j.toxrep.2018.01.008. eCollection 2018.

Protective role of .

Toxicology reports

Rupal Purena, Rohit Seth, Renu Bhatt

Affiliations

  1. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, 495009, Chhattisgarh, India.
  2. Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, 495009, Chhattisgarh, India.

PMID: 29487802 PMCID: PMC5814364 DOI: 10.1016/j.toxrep.2018.01.008

Abstract

Nephrotoxicity is a major limiting factor in cisplatin treatment. In the present study hydro-ethanolic leaf extract of

Keywords: BSA, bovine serum albumin; BUN, blood urea nitrogen; BW, body weight; CAT, catalase; Cisplatin; DMSO, dimethyl sulfoxide; DNA, deoxy-ribonucleic acid; DTNB, 5,5-dithio-bis(2-nitrobenzoic acid); Emblica officinalis; FDA, food and drug administration; GAMT, guanidinoacetate methyltransferase; GPx, glutathione peroxidase; GR, glutathione reductase; H&E, hematoxylene and eosin; MDA, malondialdehyde; NADPH, nicotinamide adenine dinucleotide phosphate; NaCl, sodium chloride; Nephrotoxicity; Oxidative stress; RBCs, red blood cells; RNS, reactive nitrogen species; ROS, reactive oxygen species; Rats; SEM, standard error mean; SOD, superoxide dismutase; TBA, 2-thiobarbituric acid; TCA, trichloroacetic acid

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