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Cline JM, Dugan G, Bourland JD, et al. Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP. Antioxidants (Basel). 2018;7(3)doi: 10.3390/antiox7030040.
Cline, J. M., Dugan, G., Bourland, J. D., Perry, D. L., Stitzel, J. D., Weaver, A. A., Jiang, C., Tovmasyan, A., Owzar, K., Spasojevic, I., Batinic-Haberle, I., & Vujaskovic, Z. (2018). Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP. Antioxidants (Basel, Switzerland), 7(3), . https://doi.org/10.3390/antiox7030040
Cline, John Mark, et al. "Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP." Antioxidants (Basel, Switzerland) vol. 7,3 (2018). doi: https://doi.org/10.3390/antiox7030040
Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z. Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP. Antioxidants (Basel). 2018 Mar 07;7(3). doi: 10.3390/antiox7030040. PMID: 29518913; PMCID: PMC5874526.
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Antioxidants (Basel). 2018 Mar 07;7(3). doi: 10.3390/antiox7030040.

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP.

Antioxidants (Basel, Switzerland)

John Mark Cline, Greg Dugan, John Daniel Bourland, Donna L Perry, Joel D Stitzel, Ashley A Weaver, Chen Jiang, Artak Tovmasyan, Kouros Owzar, Ivan Spasojevic, Ines Batinic-Haberle, Zeljko Vujaskovic

Affiliations

  1. Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA. [email protected].
  2. Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA. [email protected].
  3. Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA. [email protected].
  4. Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA. [email protected].
  5. Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Frederick, MD 21702, USA. [email protected].
  6. Department of Biomedical Engineering, Wake Forest University School of Medicine, Biotech Place, 575 N. Patterson Ave., Winston-Salem, NC 21701, USA. [email protected].
  7. Department of Biomedical Engineering, Wake Forest University School of Medicine, Biotech Place, 575 N. Patterson Ave., Winston-Salem, NC 21701, USA. [email protected].
  8. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  9. Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  10. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  11. Department of Medicine Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  12. Duke Cancer Institute, Pharmaceutical Research Shared Resource, PK/PD Core Laboratory, Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  13. Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  14. Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27708, USA. [email protected].
  15. Department of Radiation Oncology, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD 21201, USA. [email protected].

PMID: 29518913 PMCID: PMC5874526 DOI: 10.3390/antiox7030040

Abstract

Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; however, studies in humans or large animals are lacking. We hypothesized that post-exposure treatment with the lipophilic mitochondrial superoxide dismutase mimetic, MnTnHex-2-PyP

Keywords: Macaca mulatta; MnTnHex-2-PyP5+; irradiation; lung injury; superoxide dismutase mimetic

Conflict of interest statement

The authors report no declarations of interest.

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