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Liu XY, Xu HX, Li JK, et al. Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Front Physiol. 2018;9:102doi: 10.3389/fphys.2018.00102.
Liu, X. Y., Xu, H. X., Li, J. K., Zhang, D., Ma, X. H., Huang, L. N., Lü, J. H., & Wang, X. Z. (2018). Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Frontiers in physiology, 9102. https://doi.org/10.3389/fphys.2018.00102
Liu, Xiang-Yong, et al. "Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome." Frontiers in physiology vol. 9 (2018): 102. doi: https://doi.org/10.3389/fphys.2018.00102
Liu XY, Xu HX, Li JK, Zhang D, Ma XH, Huang LN, Lü JH, Wang XZ. Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Front Physiol. 2018 Feb 22;9:102. doi: 10.3389/fphys.2018.00102. eCollection 2018. PMID: 29520236; PMCID: PMC5826949.
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Front Physiol. 2018 Feb 22;9:102. doi: 10.3389/fphys.2018.00102. eCollection 2018.

Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.

Frontiers in physiology

Xiang-Yong Liu, Hai-Xiao Xu, Jian-Kui Li, Dong Zhang, Xiao-Hong Ma, Li-Na Huang, Jun-Hong Lü, Xiao-Zhi Wang

Affiliations

  1. Department of Cell Biology, Binzhou Medical University, Yantai, China.
  2. Department of Respirator Medicine and Intensive Care Unit, Affiliated Hospital of Binzhou Medical University, Binzhou, China.
  3. Division of Physical Biology and CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.

PMID: 29520236 PMCID: PMC5826949 DOI: 10.3389/fphys.2018.00102

Abstract

Damage to the endothelial glycocalyx is a critical factor in increased pulmonary vascular permeability, which is the basic pathological feature of acute respiratory distress syndrome (ARDS). Neferine (Nef), a bisbenzylisoquinoline alkaloid isolated from green seed embryos of

Keywords: acute respiratory distress syndrome; endothelial glycocalyx; lipopolysaccharide; mitochondrial ROS; neferine

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