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Ahmed I, Ahmad NS, Ali S, et al. Medication Adherence Apps: Review and Content Analysis. JMIR Mhealth Uhealth. 2018;6(3):e62doi: 10.2196/mhealth.6432.
Ahmed, I., Ahmad, N. S., Ali, S., Ali, S., George, A., Saleem Danish, H., Uppal, E., Soo, J., Mobasheri, M. H., King, D., Cox, B., & Darzi, A. (2018). Medication Adherence Apps: Review and Content Analysis. JMIR mHealth and uHealth, 6(3), e62. https://doi.org/10.2196/mhealth.6432
Ahmed, Imran, et al. "Medication Adherence Apps: Review and Content Analysis." JMIR mHealth and uHealth vol. 6,3 (2018): e62. doi: https://doi.org/10.2196/mhealth.6432
Ahmed I, Ahmad NS, Ali S, Ali S, George A, Saleem Danish H, Uppal E, Soo J, Mobasheri MH, King D, Cox B, Darzi A. Medication Adherence Apps: Review and Content Analysis. JMIR Mhealth Uhealth. 2018 Mar 16;6(3):e62. doi: 10.2196/mhealth.6432. PMID: 29549075; PMCID: PMC5878368.
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JMIR Mhealth Uhealth. 2018 Mar 16;6(3):e62. doi: 10.2196/mhealth.6432.

Medication Adherence Apps: Review and Content Analysis.

JMIR mHealth and uHealth

Imran Ahmed, Niall Safir Ahmad, Shahnaz Ali, Shair Ali, Anju George, Hiba Saleem Danish, Encarl Uppal, James Soo, Mohammad H Mobasheri, Dominic King, Benita Cox, Ara Darzi

Affiliations

  1. Undergraduate Department of Medicine, Imperial College London, London, United Kingdom.
  2. Brighton and Sussex Medical School, Brighton, United Kingdom.
  3. Division of Surgery, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  4. Institute of Global Health Innovation, Imperial College London, London, United Kingdom.
  5. Imperial College London, South Kensington Campus, London, United Kingdom.

PMID: 29549075 PMCID: PMC5878368 DOI: 10.2196/mhealth.6432

Abstract

BACKGROUND: Medication adherence is an expensive and damaging problem for patients and health care providers. Patients adhere to only 50% of drugs prescribed for chronic diseases in developed nations. Digital health has paved the way for innovative smartphone solutions to tackle this challenge. However, despite numerous apps available claiming to improve adherence, a thorough review of adherence apps has not been carried out to date.

OBJECTIVE: The aims of this study were to (1) review medication adherence apps available in app repositories in terms of their evidence base, medical professional involvement in development, and strategies used to facilitate behavior change and improve adherence and (2) provide a system of classification for these apps.

METHODS: In April 2015, relevant medication adherence apps were identified by searching the Apple App Store and the Google Play Store using a combination of relevant search terms. Data extracted included app store source, app price, documentation of health care professional (HCP) involvement during app development, and evidence base for each respective app. Free apps were downloaded to explore the strategies used to promote medication adherence. Testing involved a standardized medication regimen of three reminders over a 4-hour period. Nonadherence features designed to enhance user experience were also documented.

RESULTS: The app repository search identified a total of 5881 apps. Of these, 805 fulfilled the inclusion criteria initially and were tested. Furthermore, 681 apps were further analyzed for data extraction. Of these, 420 apps were free for testing, 58 were inaccessible and 203 required payment. Of the 420 free apps, 57 apps were developed with HCP involvement and an evidence base was identified in only 4 apps. Of the paid apps, 9 apps had HCP involvement, 1 app had a documented evidence base, and 1 app had both. In addition, 18 inaccessible apps were produced with HCP involvement, whereas 2 apps had a documented evidence base. The 420 free apps were further analyzed to identify strategies used to improve medication adherence. This identified three broad categories of adherence strategies, reminder, behavioral, and educational. A total of 250 apps utilized a single method, 149 apps used two methods, and only 22 apps utilized all three methods.

CONCLUSIONS: To our knowledge, this is the first study to systematically review all available medication adherence apps on the two largest app repositories. The results demonstrate a concerning lack of HCP involvement in app development and evidence base of effectiveness. More collaboration is required between relevant stakeholders to ensure development of high quality and relevant adherence apps with well-powered and robust clinical trials investigating the effectiveness of these interventions. A sound evidence base will encourage the adoption of effective adherence apps, and thus improve patient welfare in the process.

©Imran Ahmed, Niall Safir Ahmad, Shahnaz Ali, Shair Ali, Anju George, Hiba Saleem Danish, Encarl Uppal, James Soo, Mohammad H Mobasheri, Dominic King, Benita Cox, Ara Darzi. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 16.03.2018.

Keywords: medication adherence; mobile apps; patient compliance; reminder systems; smartphone; telemedicine; treatment outcome

References

  1. J Telemed Telecare. 2011;17(6):308-12 - PubMed
  2. Telemed J E Health. 2017 Feb;23 (2):75-79 - PubMed
  3. J Am Pharm Assoc (2003). 2016 May-Jun;56(3):293-302 - PubMed
  4. Oman Med J. 2011 May;26(3):155-9 - PubMed
  5. Ann Vasc Surg. 2013 Aug;27(6):804-9 - PubMed
  6. Colorectal Dis. 2012 Sep;14(9):e530-4 - PubMed
  7. Hernia. 2014 Aug;18(4):557-61 - PubMed
  8. Drugs Aging. 2008;25(4):307-24 - PubMed
  9. Value Health. 2008 Jan-Feb;11(1):44-7 - PubMed
  10. Am J Prev Med. 2012 Jun;42(6):630-8 - PubMed
  11. Age Ageing. 1994 Mar;23(2):113-6 - PubMed
  12. Telemed J E Health. 2016 Nov;22(11):929-937 - PubMed
  13. Am J Prev Med. 2016 May;50(5):e143-e146 - PubMed
  14. Telemed J E Health. 2014 Apr;20(4):385-7 - PubMed
  15. MedGenMed. 2005 Mar 16;7(1):4 - PubMed
  16. J Med Internet Res. 2011 Sep 22;13(3):e65 - PubMed
  17. J Med Internet Res. 2013 Mar 08;15(3):e51 - PubMed
  18. Pharm Pract (Granada). 2015 Oct-Dec;13(4):644 - PubMed
  19. BMC Sports Sci Med Rehabil. 2015 Oct 12;7:23 - PubMed
  20. J Med Internet Res. 2012 Oct 02;14(5):e129 - PubMed
  21. N Engl J Med. 2010 May 6;362(18):1698-707 - PubMed
  22. J Am Med Inform Assoc. 2012 Sep-Oct;19(5):696-704 - PubMed
  23. Obes Surg. 2014 Jan;24(1):32-6 - PubMed
  24. Biometrics. 1977 Mar;33(1):159-74 - PubMed
  25. Clin Geriatr Med. 2012 May;28(2):287-300 - PubMed
  26. PLoS One. 2015 May 18;10(5):e0125547 - PubMed
  27. BMC Geriatr. 2013 May 06;13:43 - PubMed
  28. J Am Pharm Assoc (2003). 2013 Mar-Apr;53(2):172-81 - PubMed

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