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Teo CH, Soga T, Parhar IS. Brain Beta-Catenin Signalling During Stress and Depression. Neurosignals. 2018;26(1):31-42doi: 10.1159/000487764.
Teo, C. H., Soga, T., & Parhar, I. S. (2018). Brain Beta-Catenin Signalling During Stress and Depression. Neuro-Signals, 26(1), 31-42. https://doi.org/10.1159/000487764
Teo, Chuin Hau, et al. "Brain Beta-Catenin Signalling During Stress and Depression." Neuro-Signals vol. 26,1 (2018): 31-42. doi: https://doi.org/10.1159/000487764
Teo CH, Soga T, Parhar IS. Brain Beta-Catenin Signalling During Stress and Depression. Neurosignals. 2018;26(1):31-42. doi: 10.1159/000487764. Epub 2018 Feb 22. PMID: 29490303.
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Neurosignals. 2018;26(1):31-42. doi: 10.1159/000487764. Epub 2018 Feb 22.

Brain Beta-Catenin Signalling During Stress and Depression.

Neuro-Signals

Chuin Hau Teo, Tomoko Soga, Ishwar S Parhar

Affiliations

  1. Brain Research Institute Monash Sunway (BRIMS), School of Medicine and Health Sciences, Monash University Malaysia, Sunway, Malaysia.
  2. Brain Research Institute Monash Sunway (BRIMS), School of Medicine and Health Sciences, Monash University Malaysia, Sunway, Malaysia, [email protected].

PMID: 29490303 DOI: 10.1159/000487764

Abstract

Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway. In the canonical Wnt signalling pathway, beta-catenin again plays multiple roles. In the embryonic stage, the regulation of beta-catenin levels activates genes that govern cell proliferation and differentiation. In an adult organism, beta-catenin continues to regulate the cell cycle - as a result over-expression of beta-catenin may lead to cancer. In the brain, dysfunctions in Wnt signalling related to beta-catenin levels may also cause various pathological conditions like Alzheimer's disease, Parkinson's disease, and depression. Beta-catenin can be influenced by stressful conditions and increases in glucocorticoid levels. In addition, beta-catenin can be regulated by neurotransmitters such as serotonin and dopamine. Fluctuations in beta-catenin in brain regions under duress have been associated with depressive-like behaviours. It is theorized that the change in behaviour can be attributed to the regulation of Dicer by beta-catenin. Dicer, a protein that produces micro-RNAs in the cell, is a target gene for beta-catenin. Amongst the micro-RNA that it produces are those involved in stress resilience. In this way, beta-catenin has taken its place in the well-studied biochemistry of stress and depression, and future research into this interesting protein may yet yield fruitful results in that field.

© 2018 The Author(s). Published by S. Karger AG, Basel.

Keywords: GSK3β; Glucocorticoids; Serotonin; Wnt; miRNA

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