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Kumar K, Biyyam M, Bajantri B, et al. Critical Management of Severe Hypotension Caused by Amlodipine Toxicity Managed With Hyperinsulinemia/Euglycemia Therapy Supplemented With Calcium Gluconate, Intravenous Glucagon and Other Vasopressor Support: Review of Literature. Cardiol Res. 2018;9(1):46-49doi: 10.14740/cr646w.
Kumar, K., Biyyam, M., Bajantri, B., & Nayudu, S. (2018). Critical Management of Severe Hypotension Caused by Amlodipine Toxicity Managed With Hyperinsulinemia/Euglycemia Therapy Supplemented With Calcium Gluconate, Intravenous Glucagon and Other Vasopressor Support: Review of Literature. Cardiology research, 9(1), 46-49. https://doi.org/10.14740/cr646w
Kumar, Kishore, et al. "Critical Management of Severe Hypotension Caused by Amlodipine Toxicity Managed With Hyperinsulinemia/Euglycemia Therapy Supplemented With Calcium Gluconate, Intravenous Glucagon and Other Vasopressor Support: Review of Literature." Cardiology research vol. 9,1 (2018): 46-49. doi: https://doi.org/10.14740/cr646w
Kumar K, Biyyam M, Bajantri B, Nayudu S. Critical Management of Severe Hypotension Caused by Amlodipine Toxicity Managed With Hyperinsulinemia/Euglycemia Therapy Supplemented With Calcium Gluconate, Intravenous Glucagon and Other Vasopressor Support: Review of Literature. Cardiol Res. 2018 Feb;9(1):46-49. doi: 10.14740/cr646w. Epub 2018 Feb 11. PMID: 29479386; PMCID: PMC5819629.
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Cardiol Res. 2018 Feb;9(1):46-49. doi: 10.14740/cr646w. Epub 2018 Feb 11.

Critical Management of Severe Hypotension Caused by Amlodipine Toxicity Managed With Hyperinsulinemia/Euglycemia Therapy Supplemented With Calcium Gluconate, Intravenous Glucagon and Other Vasopressor Support: Review of Literature.

Cardiology research

Kishore Kumar, Madhavi Biyyam, Bharat Bajantri, Sureshkumar Nayudu

Affiliations

  1. Division of Gastroenterology, Department of Medicine, Bronx Lebanon Hospital Center, Bronx, NY, USA.
  2. Division of Pulmonary and Critical Care, Department of Medicine, Bronx Lebanon Hospital Center, Bronx, NY, USA.

PMID: 29479386 PMCID: PMC5819629 DOI: 10.14740/cr646w

Abstract

Calcium channel blocker (CCB ) overdose, whether intentional or accidental, is a common clinical scenario and can be very lethal. Conventional treatments for CCB overdose include intravenous (IV) fluids, calcium salts, dopamine, dobutamine, norepinephrine, phosphodiesterase inhibitors, and glucagon. However, the conventional therapies are unsuccessful in reversing the cardiovascular toxicity of CCB, so they commonly fail to improve the hemodynamic condition of the patient. Blockade of the L-type calcium channels that mediate the antihypertensive effect of CCBs also decreases the release of insulin from pancreatic β-islet cells and reduces glucose uptake by tissues (insulin resistance). By targeting this insulin-mediated pathway, hyperinsulinemia/euglycemia therapy (HIET) appears to have a distinct role, and its clinical potential is underrecognized in the management of severe CCB toxicity. We present a case of young man with amlodipine toxicity successfully managed with high dose of IV insulin therapy.

Keywords: Hyperinsulinemia/euglycemia therapy; Shock; Calcium channel blocker toxicity

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

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