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Fujii Y. RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients. Clin Drug Investig. 2002;22(9):561-574doi: 10.2165/00044011-200222090-00001.
Fujii, Y. (2002). RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients. Clinical drug investigation, 22(9), 561-574. https://doi.org/10.2165/00044011-200222090-00001
Fujii, Yoshitaka. "RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients." Clinical drug investigation vol. 22,9 (2002): 561-574. doi: https://doi.org/10.2165/00044011-200222090-00001
Fujii Y. RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients. Clin Drug Investig. 2002 Sep;22(9):561-574. doi: 10.2165/00044011-200222090-00001. PMID: 29492850.
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Clin Drug Investig. 2002 Sep;22(9):561-574. doi: 10.2165/00044011-200222090-00001.

RETRACTED ARTICLE: Combination Antiemetic Regimens for Prevention of Postoperative Nausea and Vomiting : Focus on High-Risk Patients.

Clinical drug investigation

Yoshitaka Fujii

Affiliations

  1. Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Amakubo, Tsukuba City, 2-1-1, Japan. [email protected].

PMID: 29492850 DOI: 10.2165/00044011-200222090-00001

Abstract

None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade of one receptor. There is a possibility that a combination of antiemetics with different sites of activity would be more effective than one drug alone for prophylaxis against postoperative nausea and vomiting (PONV).The clinical use of combined traditional antiemetics, including antihistamines (e.g. diphenhydramine), butyrophenones (e.g. droperidol) and benzamides (e.g. metoclopramide), for the prevention of PONV is limited because of the possibility of additive central nervous system toxicity, such as delayed emergence, drowsiness and extrapyramidal reactions. The efficacy of a combination of a serotonin 5-HT

Keywords: Droperidol; Granisetron; Metoclopramide; Ondansetron; Tropisetron

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