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Shao L, Wang J, Karatas OF, et al. Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN. Oncotarget. 2018;9(18):14456-14471doi: 10.18632/oncotarget.24470.
Shao, L., Wang, J., Karatas, O. F., Feng, S., Zhang, Y., Creighton, C. J., & Ittmann, M. (2018). Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN. Oncotarget, 9(18), 14456-14471. https://doi.org/10.18632/oncotarget.24470
Shao, Longjiang, et al. "Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN." Oncotarget vol. 9,18 (2018): 14456-14471. doi: https://doi.org/10.18632/oncotarget.24470
Shao L, Wang J, Karatas OF, Feng S, Zhang Y, Creighton CJ, Ittmann M. Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN. Oncotarget. 2018 Feb 12;9(18):14456-14471. doi: 10.18632/oncotarget.24470. eCollection 2018 Mar 06. PMID: 29581856; PMCID: PMC5865682.
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Oncotarget. 2018 Feb 12;9(18):14456-14471. doi: 10.18632/oncotarget.24470. eCollection 2018 Mar 06.

Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN.

Oncotarget

Longjiang Shao, Jianghua Wang, Omer Faruk Karatas, Shu Feng, Yiqun Zhang, Chad J Creighton, Michael Ittmann

Affiliations

  1. Deptartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
  2. Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA.
  3. Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
  4. Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas 77030, USA.

PMID: 29581856 PMCID: PMC5865682 DOI: 10.18632/oncotarget.24470

Abstract

Prostate cancer is the most common visceral malignancy and the second leading cause of cancer deaths in US men. Correlative studies in human prostate cancers reveal a frequent association of the TMPRSS2/ERG (TE) fusion gene with loss of PTEN and studies in mouse models reveal that ERG expression and PTEN loss synergistically promote prostate cancer progression. To determine the mechanism by which ERG overexpression and PTEN loss leads to transformation, we overexpressed the TE fusion gene and knocked down PTEN in an immortalized but non-transformed prostate epithelial cell line. We show that ERG overexpression in combination with PTEN loss can transform these immortalized but non-tumorigenic cells, while either alteration alone was not sufficient to fully transform these cells. Expression microarray analysis revealed extensive changes in gene expression in cells expressing the TE fusion with loss of PTEN. Among these gene expression changes was increased expression of multiple FGF ligands and receptors. We show that activation of fibroblast growth factor receptor signaling plays a key role in transformation induced by TE fusion gene expression in association with PTEN loss. In addition,

Keywords: PTEN; TMPRSS2/ERG; fibroblast growth factors; prostate cancer; signal transduction

Conflict of interest statement

CONFLICTS OF INTEREST The authors disclose no potential conflicts of interest.

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