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Shen T, Li S, Cai LD, et al. Erbin exerts a protective effect against inflammatory bowel disease by suppressing autophagic cell death. Oncotarget. 2018;9(15):12035-12049doi: 10.18632/oncotarget.23925.
Shen, T., Li, S., Cai, L. D., Liu, J. L., Wang, C. Y., Gan, W. J., Li, X. M., Wang, J. R., Sun, L. N., Deng, M., Liu, Y. H., & Li, J. M. (2018). Erbin exerts a protective effect against inflammatory bowel disease by suppressing autophagic cell death. Oncotarget, 9(15), 12035-12049. https://doi.org/10.18632/oncotarget.23925
Shen, Tong, et al. "Erbin exerts a protective effect against inflammatory bowel disease by suppressing autophagic cell death." Oncotarget vol. 9,15 (2018): 12035-12049. doi: https://doi.org/10.18632/oncotarget.23925
Shen T, Li S, Cai LD, Liu JL, Wang CY, Gan WJ, Li XM, Wang JR, Sun LN, Deng M, Liu YH, Li JM. Erbin exerts a protective effect against inflammatory bowel disease by suppressing autophagic cell death. Oncotarget. 2018 Jan 04;9(15):12035-12049. doi: 10.18632/oncotarget.23925. eCollection 2018 Feb 23. PMID: 29552291; PMCID: PMC5844727.
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Oncotarget. 2018 Jan 04;9(15):12035-12049. doi: 10.18632/oncotarget.23925. eCollection 2018 Feb 23.

Erbin exerts a protective effect against inflammatory bowel disease by suppressing autophagic cell death.

Oncotarget

Tong Shen, Shi Li, Ling-Dong Cai, Jing-Lin Liu, Chu-Yi Wang, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Li-Na Sun, Min Deng, Yu-Hong Liu, Jian-Ming Li

Affiliations

  1. Department of Pathology, Soochow University Medical School, Suzhou 215123, People's Republic of China.
  2. Department of Pathology, Baoan Hospital, Southern Medical University, Shenzhen 518101, People's Republic of China.

PMID: 29552291 PMCID: PMC5844727 DOI: 10.18632/oncotarget.23925

Abstract

The pathogenesis and key functional molecules involved in inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) remain unclear. Here, we reported that Erbin, a protein required for the polarity of epithelial cells, is conserved across species and highly expressed in the intestinal mucosa in mice and zebrafish. Pathologically, Erbin expression in the intestinal mucosa was significantly decreased in DSS induced acute colitis mice, IL-10 deficient mice and clinical biopsy specimens from patients with ulcerative colitis. Moreover, Erbin deficient mice are more susceptible to experimental colitis, exhibiting more severe intestinal barrier disruption, with increased histological scores and excessive production of proinflammatory cytokines. Mechanistically, Erbin deficiency or knockdown significantly exacerbated activation of autophagic program and autophagic cell death

Keywords: Erbin; autophagy; cell death; inflammatory bowel disease

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there are no conflicts of interest.

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