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Dias CM, Valkenier H, Davis AP. Anthracene Bisureas as Powerful and Accessible Anion Carriers. Chemistry. 2018;24(23):6262-6268doi: 10.1002/chem.201800508.
Dias, C. M., Valkenier, H., & Davis, A. P. (2018). Anthracene Bisureas as Powerful and Accessible Anion Carriers. Chemistry (Weinheim an der Bergstrasse, Germany), 24(23), 6262-6268. https://doi.org/10.1002/chem.201800508
Dias, Christopher M, et al. "Anthracene Bisureas as Powerful and Accessible Anion Carriers." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 24,23 (2018): 6262-6268. doi: https://doi.org/10.1002/chem.201800508
Dias CM, Valkenier H, Davis AP. Anthracene Bisureas as Powerful and Accessible Anion Carriers. Chemistry. 2018 Apr 20;24(23):6262-6268. doi: 10.1002/chem.201800508. Epub 2018 Apr 06. PMID: 29493830; PMCID: PMC5947650.
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Chemistry. 2018 Apr 20;24(23):6262-6268. doi: 10.1002/chem.201800508. Epub 2018 Apr 06.

Anthracene Bisureas as Powerful and Accessible Anion Carriers.

Chemistry (Weinheim an der Bergstrasse, Germany)

Christopher M Dias, Hennie Valkenier, Anthony P Davis

Affiliations

  1. School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
  2. Université Libre de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, 1050, Brussels, Belgium.

PMID: 29493830 PMCID: PMC5947650 DOI: 10.1002/chem.201800508

Abstract

Synthetic anion carriers (anionophores) have potential as biomedical research tools and as treatments for conditions arising from defective natural transport systems (notably cystic fibrosis). Highly active anionophores that are readily accessible and easily deliverable are especially valuable. Previous work has resulted in steroid and trans-decalin based anionophores with exceptional activity for chloride/nitrate exchange in vesicles, but poor accessibility and deliverability. This work shows that anthracene 1,8-bisureas can fulfil all three criteria. In particular, a bis-nitrophenyl derivative is prepared in two steps from commercial starting materials, yet shows comparable transport activity to the best currently known. Moreover, unlike earlier highly active systems, it does not need to be preincorporated in test vesicles but can be introduced subsequent to vesicle formation. This transporter also shows the ability to transfer between vesicles, and is therefore uniquely effective for anion transport at low transporter loadings. The results suggest that anthracene bisureas are promising candidates for application in biological research and medicine.

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: anion transport; membranes; receptors; supramolecular chemistry; ureas

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