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Britton L, Jaskowski LA, Bridle K, et al. Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet. Cell Mol Gastroenterol Hepatol. 2018;5(3):319-331doi: 10.1016/j.jcmgh.2018.01.005.
Britton, L., Jaskowski, L. A., Bridle, K., Secondes, E., Wallace, D., Santrampurwala, N., Reiling, J., Miller, G., Mangiafico, S., Andrikopoulos, S., Subramaniam, V. N., & Crawford, D. (2018). Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet. Cellular and molecular gastroenterology and hepatology, 5(3), 319-331. https://doi.org/10.1016/j.jcmgh.2018.01.005
Britton, Laurence, et al. "Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet." Cellular and molecular gastroenterology and hepatology vol. 5,3 (2018): 319-331. doi: https://doi.org/10.1016/j.jcmgh.2018.01.005
Britton L, Jaskowski LA, Bridle K, Secondes E, Wallace D, Santrampurwala N, Reiling J, Miller G, Mangiafico S, Andrikopoulos S, Subramaniam VN, Crawford D. Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet. Cell Mol Gastroenterol Hepatol. 2018 Jan 09;5(3):319-331. doi: 10.1016/j.jcmgh.2018.01.005. eCollection 2018 Mar. PMID: 29552621; PMCID: PMC5852331.
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Cell Mol Gastroenterol Hepatol. 2018 Jan 09;5(3):319-331. doi: 10.1016/j.jcmgh.2018.01.005. eCollection 2018 Mar.

Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet.

Cellular and molecular gastroenterology and hepatology

Laurence Britton, Lesley-Anne Jaskowski, Kim Bridle, Eriza Secondes, Daniel Wallace, Nishreen Santrampurwala, Janske Reiling, Gregory Miller, Salvatore Mangiafico, Sofianos Andrikopoulos, V Nathan Subramaniam, Darrell Crawford

Affiliations

  1. Gallipoli Medical Research Institute, Greenslopes Private Hospital, Greenslopes, Queensland, Australia.
  2. The University of Queensland, Herston, Queensland, Australia.
  3. Department of Gastroenterology, Princess Alexandra Hospital, Queensland, Australia.
  4. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  5. Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
  6. Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
  7. Envoi Pathology, Kelvin Grove, Queensland, Australia.
  8. Department of Medicine, Austin Hospital University of Melbourne, Heidelberg, Victoria, Australia.

PMID: 29552621 PMCID: PMC5852331 DOI: 10.1016/j.jcmgh.2018.01.005

Abstract

BACKGROUND & AIMS: Iron has an increasingly recognized role in the regulation of adipose tissue function, including the expression of adipokines involved in the pathogenesis of nonalcoholic fatty liver disease. The cellular iron exporter, ferroportin, has been proposed as being a key determinant of adipocyte iron homeostasis.

METHODS: We studied an adipocyte-specific ferroportin (

RESULTS: We showed successful selective deletion of

CONCLUSIONS: Ferroportin may not be a key determinant of adipocyte iron homeostasis in this knockout model. Further studies are needed to determine the mechanisms of iron metabolism in adipocytes and adipose tissue.

Keywords: AAS, atomic absorption spectroscopy; ANOVA, analysis of variance; AUC, area under the curve; Adipoq, adiponectin; Adipose Tissue; EFP, epididymal fat pad; FKO, ferroportin knockout; Ferroportin; Ferroportin Flox, Fpn1fl/fl; Fpn1, ferroportin; HIC, hepatic iron concentration; Hamp1, hepcidin; Iron; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; Nonalcoholic Fatty Liver Disease; PCR, polymerase chain reaction; RBP-4, retinol binding protein-4; Tfr1, transferrin receptor-1; bp, base pair; cDNA, complementary DNA; mRNA, messenger RNA

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