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El-Jawhari JJ, Brockett CL, Ktistakis I, et al. The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells. Regen Med. 2018;doi: 10.2217/rme-2017-0104.
El-Jawhari, J. J., Brockett, C. L., Ktistakis, I., Jones, E., & Giannoudis, P. V. (2018). The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells. Regenerative medicine, . https://doi.org/10.2217/rme-2017-0104
El-Jawhari, Jehan J, et al. "The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells." Regenerative medicine vol. (2018). doi: https://doi.org/10.2217/rme-2017-0104
El-Jawhari JJ, Brockett CL, Ktistakis I, Jones E, Giannoudis PV. The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells. Regen Med. 2018 Mar 19; doi: 10.2217/rme-2017-0104. Epub 2018 Mar 19. PMID: 29553890.
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Regen Med. 2018 Mar 19; doi: 10.2217/rme-2017-0104. Epub 2018 Mar 19.

The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells.

Regenerative medicine

Jehan J El-Jawhari, Claire L Brockett, Ioannis Ktistakis, Elena Jones, Peter V Giannoudis

Affiliations

  1. Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Leeds, UK.
  2. Clinical pathology department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  3. Institute of Medical & Biological Engineering, University of Leeds, Leeds, UK.
  4. Academic Unit of Trauma and Orthopaedic Surgery, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

PMID: 29553890 DOI: 10.2217/rme-2017-0104

Abstract

The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, biological events and mechanical changes of the ankle degeneration were discussed. The regenerative therapies were reviewed versus the standard surgical treatment. We especially focused on the use of mesenchymal (multipotential) stromal cells (MSCs) highlighting their dual functions of regeneration and cell modulation with an emphasis on the emerging MSC-based clinical studies. Being at an early step, more basic and clinical research is needed to optimize the applications of all ankle regenerative therapies including MSC-based methods.

Keywords: ankle; bone; cartilage; cell therapy; mesenchymal (multipotential) stromal cells; osteoarthritis; osteochondral lesion; regeneration

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