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Nardoni M, Della Valle E, Liberti M, et al. Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?. Nanomaterials (Basel). 2018;8(4)doi: 10.3390/nano8040196.
Nardoni, M., Della Valle, E., Liberti, M., Relucenti, M., Casadei, M. A., Paolicelli, P., Apollonio, F., & Petralito, S. (2018). Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?. Nanomaterials (Basel, Switzerland), 8(4), . https://doi.org/10.3390/nano8040196
Nardoni, Martina, et al. "Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?." Nanomaterials (Basel, Switzerland) vol. 8,4 (2018). doi: https://doi.org/10.3390/nano8040196
Nardoni M, Della Valle E, Liberti M, Relucenti M, Casadei MA, Paolicelli P, Apollonio F, Petralito S. Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?. Nanomaterials (Basel). 2018 Mar 27;8(4). doi: 10.3390/nano8040196. PMID: 29584700; PMCID: PMC5923526.
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Nanomaterials (Basel). 2018 Mar 27;8(4). doi: 10.3390/nano8040196.

Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?.

Nanomaterials (Basel, Switzerland)

Martina Nardoni, Elena Della Valle, Micaela Liberti, Michela Relucenti, Maria Antonietta Casadei, Patrizia Paolicelli, Francesca Apollonio, Stefania Petralito

Affiliations

  1. Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. [email protected].
  2. Department of Information Engineering, Electronics and Telecommunications (DIET), "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy.
  3. Department of Information Engineering, Electronics and Telecommunications (DIET), "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy. [email protected].
  4. Department of Anatomical, Histological, Forensic Medicine and Orthopedic Science, "Sapienza" University of Rome, Via A. Borelli 50, 00161 Rome, Italy. [email protected].
  5. Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. [email protected].
  6. Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. [email protected].
  7. Department of Information Engineering, Electronics and Telecommunications (DIET), "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy. [email protected].
  8. Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. [email protected].

PMID: 29584700 PMCID: PMC5923526 DOI: 10.3390/nano8040196

Abstract

Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of the MNPs is used to enhance the membrane permeability. This result can be effectively achieved with low intensity non-thermal alternating magnetic field (AMF), which, however, found rare clinic application. Therefore, a different modality of generating non-thermal magnetic fields has now been investigated. Specifically, the ability of the intermittent signals generated by non-thermal pulsed electromagnetic fields (PEMFS) were used to verify if, once applied to high-transition temperature magnetoliposomes (high-Tm MLs), they could be able to efficiently trigger the release of a hydrophilic model drug. To this end, hydrophilic MNPs were combined with hydrogenated soybean phosphatidylcholine and cholesterol to design high-Tm MLs. The release of a dye was evaluated under the effect of PEMFs for different times. The MNPs motions produced by PEMF could effectively increase the bilayer permeability, without affecting the liposomes integrity and resulted in nearly 20% of release after 3 h exposure. Therefore, the current contribution provides an exciting proof-of-concept for the ability of PEMFS to trigger drug release, considering that PEMFS find already application in therapy due to their anti-inflammatory effects.

Keywords: PEMF; magneto mechanical trigger; magneto nanoparticles; magnetoliposomes; non-thermal magnetic field; on-demand drug release

Conflict of interest statement

The authors declare no conflict of interest.

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