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Vicencio-Rosas E, Pérez-Guillé MG, Flores-Pérez C, et al. Buprenorphine and pain treatment in pediatric patients: an update. J Pain Res. 2018;11:549-559doi: 10.2147/JPR.S153903.
Vicencio-Rosas, E., Pérez-Guillé, M. G., Flores-Pérez, C., Flores-Pérez, J., Trujillo-Jiménez, F., & Chávez-Pacheco, J. L. (2018). Buprenorphine and pain treatment in pediatric patients: an update. Journal of pain research, 11549-559. https://doi.org/10.2147/JPR.S153903
Vicencio-Rosas, Erendira, et al. "Buprenorphine and pain treatment in pediatric patients: an update." Journal of pain research vol. 11 (2018): 549-559. doi: https://doi.org/10.2147/JPR.S153903
Vicencio-Rosas E, Pérez-Guillé MG, Flores-Pérez C, Flores-Pérez J, Trujillo-Jiménez F, Chávez-Pacheco JL. Buprenorphine and pain treatment in pediatric patients: an update. J Pain Res. 2018 Mar 15;11:549-559. doi: 10.2147/JPR.S153903. eCollection 2018. PMID: 29588613; PMCID: PMC5859905.
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J Pain Res. 2018 Mar 15;11:549-559. doi: 10.2147/JPR.S153903. eCollection 2018.

Buprenorphine and pain treatment in pediatric patients: an update.

Journal of pain research

Erendira Vicencio-Rosas, María Gabriela Pérez-Guillé, Carmen Flores-Pérez, Janett Flores-Pérez, Francisca Trujillo-Jiménez, Juan Luis Chávez-Pacheco

Affiliations

  1. Anesthesiology Department, Hospital Regional de Alta Especialidad "Bicentenario de la Independencia", ISSSTE, Tultitlán de Mariano Escobedo, México.
  2. Pharmacology Laboratory, Instituto Nacional de Pediatría, Ciudad de México, México.

PMID: 29588613 PMCID: PMC5859905 DOI: 10.2147/JPR.S153903

Abstract

INTRODUCTION: The usual management of moderate to severe pain is based on the use of opioids. Buprenorphine (BPN) is an opioid with an analgesic potency 50 times greater than that of morphine. It is widely used in various pain models and has demonstrated efficacy and safety in adult patients; however, there are insufficient clinical trials in pediatric populations.

PURPOSE: The aim of this study was to perform an updated meta-analysis on the implementation of BPN in the treatment of pain in the pediatric population.

METHODS: A bibliographic search was carried out in different biomedical databases to identify scientific papers and clinical trials with evidence of BPN use in children and adolescents.

RESULTS: A total of 89 articles were found, of which 66 were selected. Analysis of these items revealed additional sources, and the final review included a total of 112 publications.

CONCLUSION: Few studies were found regarding the efficacy and safety of BPN use in children. In recent years, the use of this drug in the pediatric population has become widespread, so it is imperative to perform clinical trials and pharmacological and pharmacovigilance studies, which will allow researchers to develop dosage schemes based on the evidence and minimize the risk of adverse effects.

Keywords: adverse effects; analgesia; buprenorphine; child; opioid; pharmacokinetics

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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