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Camargo RY, Kanamura CT, Friguglietti CU, et al. Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient. Int J Endocrinol. 2018;2018:4682876doi: 10.1155/2018/4682876.
Camargo, R. Y., Kanamura, C. T., Friguglietti, C. U., Nogueira, C. R., Iorcansky, S., Tincani, A. J., Bezerra, A. K., Brust, E., Koyama, F. C., Camargo, A. A., Rego, F. O. R., Galante, P. A. F., Medeiros-Neto, G., & Rubio, I. G. S. (2018). Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient. International journal of endocrinology, 20184682876. https://doi.org/10.1155/2018/4682876
Camargo, Rosalinda Yasato, et al. "Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient." International journal of endocrinology vol. 2018 (2018): 4682876. doi: https://doi.org/10.1155/2018/4682876
Camargo RY, Kanamura CT, Friguglietti CU, Nogueira CR, Iorcansky S, Tincani AJ, Bezerra AK, Brust E, Koyama FC, Camargo AA, Rego FOR, Galante PAF, Medeiros-Neto G, Rubio IGS. Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient. Int J Endocrinol. 2018 Feb 08;2018:4682876. doi: 10.1155/2018/4682876. eCollection 2018. PMID: 29593791; PMCID: PMC5822907.
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Int J Endocrinol. 2018 Feb 08;2018:4682876. doi: 10.1155/2018/4682876. eCollection 2018.

Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient.

International journal of endocrinology

Rosalinda Yasato Camargo, Cristina Takami Kanamura, Celso Ubirajara Friguglietti, Célia Regina Nogueira, Sonia Iorcansky, Alfio José Tincani, Ana Karina Bezerra, Ester Brust, Fernanda Christtanini Koyama, Anamaria Aranha Camargo, Fernanda Orpinelli R Rego, Pedro Alexandre Favoretto Galante, Geraldo Medeiros-Neto, Ileana Gabriela Sanchez Rubio

Affiliations

  1. Thyroid Unit, Cellular and Molecular Endocrine Laboratory, LIM-25, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Doutor Arnaldo 455, Cerqueira César, 01246-904 São Paulo, SP, Brazil.
  2. Adolfo Lutz Institute, São Paulo Public Health Service, Av. Dr. Arnaldo 355, Cerqueira César, 01246-000 São Paulo, SP, Brazil.
  3. Head and Neck Surgery of Santa Catarina Hospital, Av. Paulista 200, Bela Vista, 01310-000 São Paulo, SP, Brazil.
  4. Department of Internal Medicine, Botucatu School of Medicine, UNESP, Av. Prof. Montenegro, s/n Distrito de Rubião Junior, 18618-687 Botucatu, SP, Brazil.
  5. Servicio de Endocrinología, Hospital de Pediatría Dr. Juan Garrahan, Combate de los Pozos 1881, C1245AAM Buenos Aires, Argentina.
  6. Departamento de Cirurgia na Disciplina de Cirurgia de Cabeça e Pescoço da Faculdade de Ciências Médicas da UNICAMP, R. Tessália Vieira de Camargo 126, 13083-887 Campinas, SP, Brazil.
  7. Medicine School, Universidade de Fortaleza (Unifor), Av. Washington Soares 1321, Edson Queiroz, 60811-905 Fortaleza, CE, Brazil.
  8. Postgraduate Program in Biotechnology, Universidade Federal de São Paulo (UNIFESP), Pedro de Toledo 669, 040399-032 São Paulo, SP, Brazil.
  9. Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, Departamento de Ciências Biológicas, Postgraduation Programs in Biotechnology and Structural and Functional Biology, UNIFESP, Pedro de Toledo 669, 040399-032 São Paulo, SP, Brazil.
  10. Molecular Oncology Center, Hospital Sírio-Libanés, Rua Prof. Daher Cutait 69, 01308-060 São Paulo, SP, Brazil.

PMID: 29593791 PMCID: PMC5822907 DOI: 10.1155/2018/4682876

Abstract

Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles; one sample exhibited a normal thyroid pattern while four showed colloid goiter. All ectopic thyroids expressed the specific thyroid genes and T4 at similar locations to those observed in normal thyroid. No somatic mutations associated with ectopic thyroid were found. This is the first immature thyroid fetal tissue observed in an ectopic thyroid due to the arrest of structural differentiation early in the colloid stage of development that proved able to synthesize thyroid hormone but not to respond to TSH. Despite the ability of all ectopic thyroids to synthetize specific thyroid proteins and T4, at some point in life, it may be insufficient to support body growth leading to hypothyroidism, as observed in some of the patients.

References

  1. Horm Res Paediatr. 2015;83(2):79-85 - PubMed
  2. PLoS One. 2011;6(6):e21351 - PubMed
  3. Anat Rec. 1964 Jul;149:363-79 - PubMed
  4. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S13-6 - PubMed
  5. Nat Rev Genet. 2009 Apr;10(4):233-40 - PubMed
  6. J Clin Endocrinol Metab. 2012 Mar;97(3):951-6 - PubMed
  7. Eur J Endocrinol. 2002 Feb;146(2):163-71 - PubMed
  8. BMC Genomics. 2012 Apr 24;13:147 - PubMed
  9. J Clin Endocrinol Metab. 2010 Apr;95(4):1981-5 - PubMed
  10. Dev Biol. 2008 Jul 15;319(2):336-45 - PubMed
  11. Circ Res. 2004 Jun 11;94(11):1500-6 - PubMed
  12. Sleep Med. 2004 Nov;5(6):605-7 - PubMed
  13. Nat Methods. 2014 Apr;11(4):361-2 - PubMed
  14. BMC Endocr Disord. 2015 Nov 18;15:70 - PubMed
  15. J Pediatr Endocrinol Metab. 2010 Aug;23(8):815-26 - PubMed
  16. Hum Mol Genet. 2017 Feb 1;26(3):599-610 - PubMed
  17. Am J Surg Pathol. 2011 Jun;35(6):816-26 - PubMed
  18. J Clin Endocrinol Metab. 2011 Dec;96(12 ):E2039-44 - PubMed
  19. Mol Cell Endocrinol. 2010 Jul 8;323(1):35-54 - PubMed
  20. Dev Dyn. 2009 Mar;238(3):503-13 - PubMed
  21. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4060-4071 - PubMed
  22. Endocrinology. 2005 Dec;146(12 ):5038-47 - PubMed
  23. Thyroid. 2005 Dec;15(12 ):1407-8 - PubMed
  24. Endocr Rev. 2004 Oct;25(5):722-46 - PubMed
  25. PLoS One. 2012;7(10):e46688 - PubMed
  26. J Clin Endocrinol Metab. 2007 Jan;92(1):70-6 - PubMed
  27. J Clin Endocrinol Metab. 2011 Aug;96(8):2422-9 - PubMed
  28. Acta Cytol. 1983 Mar-Apr;27(2):188-92 - PubMed
  29. Nat Genet. 1998 Aug;19(4):395-8 - PubMed
  30. Dev Biol. 2004 Dec 15;276(2):464-75 - PubMed
  31. PLoS One. 2013 May 13;8(5):e62849 - PubMed
  32. J Thyroid Res. 2011;2011:159703 - PubMed
  33. Dev Biol. 2003 Nov 1;263(1):67-80 - PubMed
  34. Eur J Endocrinol. 2011 Sep;165(3):375-82 - PubMed
  35. Ann Thorac Cardiovasc Surg. 2007 Apr;13(2):122-4 - PubMed
  36. Sao Paulo Med J. 2004 Mar 4;122(2):67-9 - PubMed
  37. Mol Endocrinol. 2011 Oct;25(10):1819-30 - PubMed
  38. PLoS One. 2011;6(9):e25162 - PubMed
  39. Thyroid. 2011 Jan;21(1):13-8 - PubMed
  40. Mol Endocrinol. 2011 Sep;25(9):1579-99 - PubMed
  41. Anat Embryol (Berl). 1983;166(3):439-51 - PubMed
  42. Cancer Res. 2016 Mar 1;76(5):1237-44 - PubMed
  43. Thyroid. 2007 Nov;17 (11):1117-21 - PubMed
  44. J Clin Endocrinol Metab. 2010 Jul;95(7):3446-52 - PubMed
  45. Am J Hum Genet. 2011 Apr 8;88(4):440-9 - PubMed
  46. Thyroid. 2007 Mar;17(3):203-11 - PubMed
  47. J Chin Med Assoc. 2010 Apr;73(4):219-21 - PubMed
  48. J Clin Endocrinol Metab. 2005 Jan;90(1):455-62 - PubMed
  49. G Chir. 1999 Mar;20(3):97-9 - PubMed
  50. Mol Cell Endocrinol. 2010 Jun 30;322(1-2):64-71 - PubMed
  51. J Clin Endocrinol Metab. 2014 Jun;99(6):E1120-9 - PubMed
  52. Endocrinology. 1978 May;102(5):1576-86 - PubMed
  53. Nucleic Acids Res. 2010 Sep;38(16):e164 - PubMed
  54. J Clin Endocrinol Metab. 2001 May;86(5):2009-14 - PubMed
  55. PLoS One. 2010 Oct 15;5(10):e13420 - PubMed
  56. Thyroid. 2011 Aug;21(8):821-7 - PubMed
  57. Clin Biochem Rev. 2011 Nov;32(4):165-75 - PubMed

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