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Nacif MS, Raman FS, Gai N, et al. Myocardial T1 mapping and determination of partition coefficients at 3 tesla: comparison between gadobenate dimeglumine and gadofosveset trisodium. Radiol Bras. 2018;51(1):13-19doi: 10.1590/0100-3984.2016.0071.
Nacif, M. S., Raman, F. S., Gai, N., Jones, J., van der Geest, R. J., T Sibley, C., Liu, S., & David, A. B. (2018). Myocardial T1 mapping and determination of partition coefficients at 3 tesla: comparison between gadobenate dimeglumine and gadofosveset trisodium. Radiologia brasileira, 51(1), 13-19. https://doi.org/10.1590/0100-3984.2016.0071
Nacif, Marcelo Souto, et al. "Myocardial T1 mapping and determination of partition coefficients at 3 tesla: comparison between gadobenate dimeglumine and gadofosveset trisodium." Radiologia brasileira vol. 51,1 (2018): 13-19. doi: https://doi.org/10.1590/0100-3984.2016.0071
Nacif MS, Raman FS, Gai N, Jones J, van der Geest RJ, T Sibley C, Liu S, David AB. Myocardial T1 mapping and determination of partition coefficients at 3 tesla: comparison between gadobenate dimeglumine and gadofosveset trisodium. Radiol Bras. 2018 Jan-Feb;51(1):13-19. doi: 10.1590/0100-3984.2016.0071. PMID: 29559761; PMCID: PMC5846320.
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Radiol Bras. 2018 Jan-Feb;51(1):13-19. doi: 10.1590/0100-3984.2016.0071.

Myocardial T1 mapping and determination of partition coefficients at 3 tesla: comparison between gadobenate dimeglumine and gadofosveset trisodium.

Radiologia brasileira

Marcelo Souto Nacif, Fabio S Raman, Neville Gai, Jacquin Jones, Rob J van der Geest, Christopher T Sibley, Songtao Liu, A Bluemke David

Affiliations

  1. MD, PhD, Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil, National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.
  2. Biomedical Engineer, National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.
  3. MD, National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.
  4. PhD, National Institutes of Health Clinical Center, Bethesda, MD, USA.
  5. PhD, Leids Universitair Medisch Centrum, Zuid-Holland, the Netherlands.
  6. MD, PhD, National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.

PMID: 29559761 PMCID: PMC5846320 DOI: 10.1590/0100-3984.2016.0071

Abstract

OBJECTIVE: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gadobenate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient.

MATERIALS AND METHODS: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as Δ

RESULTS: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being -7.6 ± 60 ms (

CONCLUSION: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.

Keywords: Contrast media; Gadolinium; Gadolinium DTPA; Magnetic resonance imaging/methods; Myocardium/pathology; Organometallic compounds

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