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Stem Cells Int. 2018 Jan 21;2018:4658503. doi: 10.1155/2018/4658503. eCollection 2018.

Injected Human Muscle Precursor Cells Overexpressing PGC-1.

Stem cells international

Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M Ametamey, Daniel Eberli

Affiliations

  1. Department of Urology, Laboratory for Tissue Engineering and Stem Cell Therapy, University Hospital Zürich, University of Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
  2. Institute for Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.
  3. Zürich Center for Integrative Human Physiology (ZIHP), Zürich, Switzerland.
  4. Biozentrum, Focal Area Growth and Development, University of Basel, Klingelbergstrasse 50-70, 4056 Basel, Switzerland.

PMID: 29531537 PMCID: PMC5827889 DOI: 10.1155/2018/4658503

Abstract

While many groups demonstrated new muscle tissue formation after muscle precursor cell (MPC) injection, the capacity of these cells to heal muscle damage, for example, sphincter in stress urinary incontinence, in long-term is still limited. Therefore, the first goal of our project was to optimize the functional regenerative potential of hMPC by genetic modification to overexpress human peroxisome proliferator-activated receptor gamma coactivator 1-alpha (hPGC-1

References

  1. Physiol Rev. 2011 Oct;91(4):1447-531 - PubMed
  2. Methods. 2009 Feb;47(2):98-103 - PubMed
  3. Semin Immunopathol. 2014 Jan;36(1):27-53 - PubMed
  4. Eur J Nucl Med Mol Imaging. 2005 Dec;32 Suppl 2:S384-403 - PubMed
  5. Int J Gynaecol Obstet. 2012 May;117(2):164-7 - PubMed
  6. J Nucl Med. 2016 Sep;57(9):1467-73 - PubMed
  7. Trends Pharmacol Sci. 2009 Jun;30(6):322-9 - PubMed
  8. BJU Int. 2008 Sep;102(7):878-84 - PubMed
  9. J Tissue Eng Regen Med. 2017 Feb;11(2):447-458 - PubMed
  10. J Neurochem. 1995 Nov;65(5):2105-15 - PubMed
  11. Nature. 1999 Sep 23;401(6751):390-4 - PubMed
  12. Nature. 2006 Jun 29;441(7097):1080-6 - PubMed
  13. Nature. 2002 Aug 15;418(6899):797-801 - PubMed
  14. Dev Biol. 1986 May;115(1):140-7 - PubMed
  15. Lancet. 2001 Sep 1;358(9283):727-9 - PubMed
  16. Cell Tissue Res. 1987 Oct;250(1):141-8 - PubMed
  17. J Physiol. 2003 Feb 1;546(Pt 3):851-8 - PubMed
  18. Nature. 1990 Jan 11;343(6254):170-3 - PubMed
  19. Genes Dev. 2007 Apr 1;21(7):770-83 - PubMed
  20. Nature. 2008 Jul 24;454(7203):463-9 - PubMed
  21. Mol Biol Cell. 2008 Mar;19(3):994-1006 - PubMed
  22. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21401-6 - PubMed
  23. Cell Transplant. 2017 Jun 9;26(6):1103-1114 - PubMed
  24. Mech Ageing Dev. 1982 Dec;20(4):377-83 - PubMed
  25. J Cell Physiol. 1989 Feb;138(2):311-5 - PubMed
  26. Mol Ther. 2008 Oct;16(10 ):1761-9 - PubMed
  27. J Nucl Med. 2010 Jun;51(6):951-8 - PubMed
  28. Transplantation. 2003 Oct 15;76(7):1053-60 - PubMed
  29. Curr Opin Rheumatol. 2011 Nov;23(6):568-73 - PubMed
  30. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16260-5 - PubMed
  31. Gastroenterology. 2005 Jun;128(7):1787-95 - PubMed
  32. Development. 2012 Aug;139(16):2845-56 - PubMed
  33. Mol Ther. 2014 Jul;22(7):1243-1253 - PubMed
  34. J Physiol Pharmacol. 2014 Apr;65(2):193-207 - PubMed
  35. Nat Clin Pract Oncol. 2009 Jan;6(1):53-8 - PubMed
  36. Clin Geriatr Med. 2011 Aug;27(3):423-47 - PubMed
  37. Cell Transplant. 2009;18(7):695-707 - PubMed
  38. Br J Urol. 1981 Feb;53(1):35-41 - PubMed
  39. FEBS Lett. 2008 Jan 9;582(1):46-53 - PubMed
  40. Nucl Med Commun. 2006 Aug;27(8):611-7 - PubMed
  41. Adv Drug Deliv Rev. 2015 Mar;82-83:168-175 - PubMed

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