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ERJ Open Res. 2018 Mar 23;4(1). doi: 10.1183/23120541.00130-2017. eCollection 2018 Jan.

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.

ERJ open research

Alice C-H Chen, Hai B Tran, Yang Xi, Stephanie T Yerkovich, Katherine J Baines, Susan J Pizzutto, Melanie Carroll, Avril A B Robertson, Matthew A Cooper, Kate Schroder, Jodie L Simpson, Peter G Gibson, Greg Hodge, Ian B Masters, Helen M Buntain, Helen L Petsky, Samantha J Prime, Anne B Chang, Sandra Hodge, John W Upham

Affiliations

  1. Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
  2. Joint first authors.
  3. Dept of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.
  4. The Prince Charles Hospital, Brisbane, Australia.
  5. The University of Newcastle, Newcastle, Australia.
  6. Child Health Division, Menzies School of Health Research, Charles Darwin Hospital, Darwin, Australia.
  7. Institute for Molecular Bioscience, Brisbane, Australia.
  8. Dept of Medicine, The University of Adelaide, Adelaide, Australia.
  9. Respiratory and Sleep Medicine, Lady Cilento Children's Hospital and Children's Centre for Health Research, Queensland University of Technology, Brisbane, Australia.
  10. Wesley Hospital, Brisbane, Australia.
  11. School of Nursing and Midwifery, Menzies Health Institute Queensland, Griffith University, Brisbane, Australia.
  12. Queensland University of Technology, Brisbane, Australia.
  13. Joint senior authors.

PMID: 29594175 PMCID: PMC5868518 DOI: 10.1183/23120541.00130-2017

Abstract

Protracted bacterial bronchitis (PBB) in young children is characterised by prolonged wet cough, prominent airway interleukin (IL)-1β expression and infection, often with nontypeable

Conflict of interest statement

Conflict of interest: None declared.

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