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Nordman H, Voutilainen R, Antikainen L, et al. Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children. J Endocr Soc. 2018;2(3):232-239doi: 10.1210/js.2017-00437.
Nordman, H., Voutilainen, R., Antikainen, L., & Jääskeläinen, J. (2018). Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children. Journal of the Endocrine Society, 2(3), 232-239. https://doi.org/10.1210/js.2017-00437
Nordman, Henrikki, et al. "Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children." Journal of the Endocrine Society vol. 2,3 (2018): 232-239. doi: https://doi.org/10.1210/js.2017-00437
Nordman H, Voutilainen R, Antikainen L, Jääskeläinen J. Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children. J Endocr Soc. 2018 Feb 02;2(3):232-239. doi: 10.1210/js.2017-00437. eCollection 2018 Mar 01. PMID: 29594257; PMCID: PMC5841182.
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J Endocr Soc. 2018 Feb 02;2(3):232-239. doi: 10.1210/js.2017-00437. eCollection 2018 Mar 01.

Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children.

Journal of the Endocrine Society

Henrikki Nordman, Raimo Voutilainen, Leena Antikainen, Jarmo Jääskeläinen

Affiliations

  1. Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, FI-70211 Kuopio, Finland.

PMID: 29594257 PMCID: PMC5841182 DOI: 10.1210/js.2017-00437

Abstract

CONTEXT: Birth size has an impact on later cardiometabolic risk that is strongly related to low-grade inflammation.

OBJECTIVE: To evaluate plasma interleukin-1 receptor antagonist (IL-1ra) concentrations in relation to birth size and cardiometabolic and inflammatory markers in prepubertal children.

DESIGN: A cohort study. Anthropometric data were recorded. Fasting blood samples were collected for plasma analyses of IL-1ra, alanine transaminase, total cholesterol, high- and low-density lipoprotein cholesterols, triglyceride, glucose, and serum analyses of 25-hydroxyvitamin D [25(OH)D] and high-sensitivity C-reactive protein (hs-CRP) concentrations.

PARTICIPANTS: Forty-nine large for gestational age (LGA), 56 appropriate for gestational age, and 23 small for gestational age (SGA) children at 5 to 8 years of age were examined.

MAIN OUTCOME MEASURES: Differences in IL-1ra concentrations among the birth-size groups and associations between IL-1ra and other metabolic markers were assessed.

RESULTS: Body mass index (BMI) standard deviation score (SDS)-adjusted plasma IL-1ra concentrations were highest in the SGA- and lowest in the LGA-born children (

CONCLUSIONS: Prepubertal children born SGA had the highest and those born LGA the lowest IL-1ra concentrations in this study cohort. Most associations found between IL-1ra and the studied metabolic parameters were weight related, but the association with hs-CRP remained strong after adjustment for BMI. It seems that at prepuberty, SGA children have a stronger inflammatory state than LGA children and may thus be at a greater risk for later metabolic disturbances.

Keywords: birth size; cardiometabolic risk; catch-up growth; large for gestational age; low-grade inflammation; small for gestational age

Conflict of interest statement

The funders had no role in the following: (1) study design; (2) the collection, analysis, and interpretation of data; (3) the writing of the report; and (4) the decision to submit the paper for public

References

  1. Cytokine. 2015 Oct;75(2):280-90 - PubMed
  2. Pediatr Diabetes. 2008 Oct;9(5):464-71 - PubMed
  3. Eur J Endocrinol. 2016 Nov;175(5):367-77 - PubMed
  4. Curr Opin Endocrinol Diabetes Obes. 2007 Feb;14(1):30-4 - PubMed
  5. Pediatr Res. 2018 Jan 23;:null - PubMed
  6. Horm Res Paediatr. 2016;85(1):11-7 - PubMed
  7. Blood. 2011 Apr 7;117(14):3720-32 - PubMed
  8. Diabetes Care. 2009 Mar;32(3):421-3 - PubMed
  9. Pediatr Diabetes. 2006 Oct;7(5):260-6 - PubMed
  10. Endocr Rev. 2007 Apr;28(2):219-51 - PubMed
  11. Pediatr Res. 2017 Aug;82(2):285-289 - PubMed
  12. Cardiovasc Pathol. 2013 Jan-Feb;22(1):16-8 - PubMed
  13. Med Chem. 2014;10(7):643-52 - PubMed
  14. Nutr Metab Cardiovasc Dis. 2012 Mar;22(3):285-91 - PubMed
  15. Trends Endocrinol Metab. 2015 Oct;26(10 ):551-563 - PubMed
  16. BMC Public Health. 2008 Sep 22;8:324 - PubMed
  17. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E15-26 - PubMed
  18. Nat Immunol. 2011 Mar;12(3):204-12 - PubMed
  19. JAMA. 2008 Dec 24;300(24):2886-97 - PubMed
  20. Ann Med. 2011 May;43(3):235-48 - PubMed
  21. Eur Heart J. 2008 Apr;29(8):1049-56 - PubMed
  22. Clin Endocrinol (Oxf). 2011 Sep;75(3):335-41 - PubMed
  23. Obesity (Silver Spring). 2012 Aug;20(8):1662-8 - PubMed
  24. Diabetes Care. 2010 Nov;33(11):2468-70 - PubMed
  25. Paediatr Int Child Health. 2015 May;35(2):110-23 - PubMed
  26. J Clin Endocrinol Metab. 2002 Mar;87(3):1184-8 - PubMed
  27. Pediatrics. 2011 May;127(5):e1272-9 - PubMed
  28. Diabetes. 2003 May;52(5):1104-10 - PubMed
  29. Obes Rev. 2005 May;6(2):143-54 - PubMed
  30. Exp Clin Endocrinol Diabetes. 2014 Jun;122(6):363-7 - PubMed
  31. Pediatr Diabetes. 2013 Dec;14(8):585-92 - PubMed
  32. Am J Cardiol. 2005 Aug 1;96(3):399-404 - PubMed
  33. J Clin Invest. 2002 Sep;110(6):851-60 - PubMed
  34. Am J Clin Nutr. 2007 Mar;85(3):845-52 - PubMed
  35. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1222-1227 - PubMed
  36. Horm Res Paediatr. 2012;78(5-6):288-96 - PubMed

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