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Dawood M, Lateef N, Tauseef A, et al. Association of Hypertrophic Obstructive Cardiomyopathy with Rheumatoid Arthritis. Cureus. 2018;10(1):e2028doi: 10.7759/cureus.2028.
Dawood, M., Lateef, N., Tauseef, A., & Patel, J. (2018). Association of Hypertrophic Obstructive Cardiomyopathy with Rheumatoid Arthritis. Cureus, 10(1), e2028. https://doi.org/10.7759/cureus.2028
Dawood, Mustafa, et al. "Association of Hypertrophic Obstructive Cardiomyopathy with Rheumatoid Arthritis." Cureus vol. 10,1 (2018): e2028. doi: https://doi.org/10.7759/cureus.2028
Dawood M, Lateef N, Tauseef A, Patel J. Association of Hypertrophic Obstructive Cardiomyopathy with Rheumatoid Arthritis. Cureus. 2018 Jan 05;10(1):e2028. doi: 10.7759/cureus.2028. PMID: 29531881; PMCID: PMC5837261.
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Cureus. 2018 Jan 05;10(1):e2028. doi: 10.7759/cureus.2028.

Association of Hypertrophic Obstructive Cardiomyopathy with Rheumatoid Arthritis.

Cureus

Mustafa Dawood, Noman Lateef, Abubakar Tauseef, Janki Patel

Affiliations

  1. General Internal Medicine, Greater Baltimore Medical Center.
  2. Department of Medicine, Dow University of Health Sciences (DUHS), Karachi, Pakistan.

PMID: 29531881 PMCID: PMC5837261 DOI: 10.7759/cureus.2028

Abstract

Our article refers to a 50-year-old woman with previously diagnosed rheumatoid arthritis (RA) who presented with symptoms of dyspnea on exertion and dizziness. An echocardiogram revealed a 17-mm asymmetric interventricular septum hypertrophy and systolic anterior motion of the anterior mitral valve leaflet. Association of hypertrophic obstructive cardiomyopathy (HCM) with connective tissue diseases has been well documented. For RA the human leukocyte antigen (HLA) system, particularly HLA-DR4, may possibly be a link between the two entities, as it is associated with both RA and HCM. Therefore, a patient with RA and suggestive history should be investigated for cardiac involvement. Further studies are needed to elucidate a more accurate association between the above diseases.

Keywords: autoimmune diseases; echocardiography; hla-dr antigens; hypertrophic obstructive cardiomyopathy; rheumatoid arthritis

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Ann Intern Med. 1963 Jan;58:102-23 - PubMed
  2. Mayo Clin Proc. 2001 Jan;76(1):111 - PubMed
  3. Exp Clin Cardiol. 2009 Spring;14(1):e21-2 - PubMed
  4. Circulation. 2004 Aug 31;110(9):1047-53 - PubMed
  5. Arthritis Rheum. 2001 Apr;45(2):129-35 - PubMed
  6. Am Heart J. 2013 Oct;166(4):622-628.e1 - PubMed
  7. Int J Mol Med. 2003 Jan;11(1):13-6 - PubMed
  8. Circulation. 2005 Jul 12;112(2):293-6 - PubMed
  9. Z Rheumatol. 1984 Mar-Apr;43(2):97-9 - PubMed
  10. Arthritis Res. 2000;2(3):217-20 - PubMed

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