Display options
Cite
Haffner M, Heyrani N, Meehan JP, et al. Enoxaparin-induced skin necrosis at injection site after total knee arthroplasty. Arthroplast Today. 2017;4(1):10-14doi: 10.1016/j.artd.2017.09.006.
Haffner, M., Heyrani, N., Meehan, J. P., & Giordani, M. (2018). Enoxaparin-induced skin necrosis at injection site after total knee arthroplasty. Arthroplasty today, 4(1), 10-14. https://doi.org/10.1016/j.artd.2017.09.006
Haffner, Max, et al. "Enoxaparin-induced skin necrosis at injection site after total knee arthroplasty." Arthroplasty today vol. 4,1 (2018): 10-14. doi: https://doi.org/10.1016/j.artd.2017.09.006
Haffner M, Heyrani N, Meehan JP, Giordani M. Enoxaparin-induced skin necrosis at injection site after total knee arthroplasty. Arthroplast Today. 2017 Oct 21;4(1):10-14. doi: 10.1016/j.artd.2017.09.006. eCollection 2018 Mar. PMID: 29560388; PMCID: PMC5859518.
Copy Download .nbib Format: NLM
Share it on

Arthroplast Today. 2017 Oct 21;4(1):10-14. doi: 10.1016/j.artd.2017.09.006. eCollection 2018 Mar.

Enoxaparin-induced skin necrosis at injection site after total knee arthroplasty.

Arthroplasty today

Max Haffner, Nasser Heyrani, John P Meehan, Mauro Giordani

Affiliations

  1. Department of Orthopaedics, University of California, Sacramento, CA, USA.

PMID: 29560388 PMCID: PMC5859518 DOI: 10.1016/j.artd.2017.09.006

Abstract

Enoxaparin is a widely used low-molecular-weight heparin for perioperative thromboembolic prophylaxis. Enoxaparin-induced skin necrosis in the setting of arthroplasty has been rarely reported in the literature with varying outcomes and management decisions. Our patient developed skin necrosis at his injection site and thrombocytopenia 10 days following left total knee arthroplasty surgery and after receiving subcutaneous Lovenox injections postoperatively. The patient was started on an alternative anticoagulation based on a high suspicion for heparin-induced thrombocytopenia and the wound was monitored without surgical debridement. Our case highlights the key clinical management decisions when facing this potentially life-threatening adverse reaction.

Keywords: Adverse reaction; Arthroplasty; Enoxaparin; Lovenox; Skin necrosis

References

  1. Chest. 2012 Feb;141(2 Suppl):7S-47S - PubMed
  2. J Bone Joint Surg Am. 2012 Apr 18;94(8):746-7 - PubMed
  3. Am J Med. 2014 Jul;127(7):598-600 - PubMed
  4. J Am Coll Clin Wound Spec. 2015 Mar 18;5(3):66-8 - PubMed
  5. Blood. 2012 Nov 15;120(20):4160-7 - PubMed
  6. N Engl J Med. 1995 May 18;332(20):1330-5 - PubMed
  7. Ann Surg. 1979 Nov;190(5):595-608 - PubMed
  8. Arch Dermatol. 1983 May;119(5):400-3 - PubMed
  9. Am J Ther. 2007 Jul-Aug;14(4):408-10 - PubMed
  10. Postgrad Med. 2012 Nov;124(6):36-42 - PubMed
  11. Am J Orthop (Belle Mead NJ). 2011 Aug;40(8):E152-3 - PubMed
  12. Case Rep Orthop. 2014;2014:139218 - PubMed
  13. J Pharm Biomed Anal. 2013 Jul-Aug;81-82:138-45 - PubMed

Publication Types